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Demonstrating the applicability of novel indices of immunological tolerance to clinical practice using immunosuppression-free transplant recipients

Objective

Patients who have received transplants generally require life-long immunosuppressive drugs, which are all associated with potentially life- threatening adverse effects. Occasionally, "tolerant" patients have been able to stop these drugs without losing their grafts, but we cannot differentiate them from others in whom stopping these drugs will result in rejection. In this project, specimens will be collected from tolerant patients and used in a series of novel, tests of immunological reactivity which have been developed by the consortium. An adequate number of such rare patients could only be collected from within a very large population, necessitating a collaboration of this size. We predict that this will reveal a tolerant "fingerprint' which can then be used to identify those whose drugs can be stopped and to define drug protocols which can induce tolerance.

Funding Scheme

DEM - Demonstration contracts

Coordinator

CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
Address
Boulevard Jean Monnet 30
44035 Nantes
France

Participants (4)

HUMBOLDT-UNIVERSITAET BERLIN
Germany
Address
Schumannstrasse 20-21
10117 Berlin
MEMOREC BIOTEC GMBH
Germany
Address
Stoeckheimer Weg 1
50829 Koeln
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
John Radcliffe Hospital
OX3 9DU Oxford
Universite Libre de Bruxelles
Belgium
Address
Avenue Franklin Roosevelt 50
Bruxelles