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Molecular changes and genetic susceptibility in relation to air pollution and environmental tobacco smoke


- To study the effects of air pollution and Environmental Tobacco Smoke (ETS) on cancers of the lung, bladder, pharynx, and larynx, plus COPD emphysema in non-smokers in nine European countries. This will be done with a nested case-cohort design in the EPIC investigation (450000 volunteers already recruited), by the means of biomarkers to exposure and susceptibility. In total 1000 randomly chosen controls will be analysed.
- To assess exposure levels by expert interpretation of already available questionnaires plus objective information on air pollution in different European cities. Exposure to ETS will also be assessed by measuring cotinine in the blood.
- To assess the effect of dose and length of exposure to environmental polluants on biological endpoints, such as DNA and hemoglobin adducts. Hemoglobin and WBC-DNA adducts formed by nitropyrenes, PAHs and other environmental contaminants (mainly due to traffic pollution and occupational exposures) will be measured. The adduct technology allows at least a partial separation of different sources of exposure (nitroarene adducts refer mainly to diesel exhaust, 4-aminobiphenyl-hemoglobin adducts to active or Environmental Tobacco Smoke).
- To study the relationship between adducts and disease according to genotypes for metabolism of the relevant carcinogens and DNA according to a newly developed technique.
- To evaluate the prote

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CSC - Cost-sharing contracts


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