Skip to main content

The mechanistic basis for providing a realistic cancer risk assesment for exposure to inorganic arsenic within the european comunity

Objective

Exposure to inorganic arsenis from different sources is a major public health concern in many regions. In accordance with existing EU Guildelines for cancer risk assessment, and that is based on mechanism of action, the general aim of this project is to define "virtually safe " levels for arsenic based on elucidation of the basic process underlying the induction of genotoxic effects and cancer, taking into consideration differences in ethnical and individual susceptibility. While considering other mechanisms, like inhibition of p53 tumour suppresor gene function and somatic recombination and synergistic effects, one major task of this project is to demonstrate if arsenic inhibits DNA-repair in humans, a type of mechanism that implies a dose threshold for carcinogenic action. The dose-response relationship for in vivo induction of chromosomal aberrations will also be defined. A second major task is to explore the relation between detoxification (methylation ) patterns, genetic polymorphism and susceptibility to the chronic toxic action of arsenic. .

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

STOCKHOLM UNIVERSITET
Address
Universitetsvaegen 10
10691 Stockholm
Sweden

Participants (6)

AUTONOMOUS UNIVERSITY OF BARCELONA
Spain
Address
Campus De Bellaterra
08193 Bellaterra
GEORG-AUGUST-UNIVERSITY GOETTINGEN
Germany
Address
Wilhelmsplatz 1
37073 Goettingen
KAROLINSKA INSTITUTE
Sweden
Address
Haelsvaegen 7
141 57 Huddinge
LEIDEN UNIVERSITY
Netherlands
Address
Wassenaarseweg 72
2300 RA Leiden
THE NOFER INSTITUTE OF OCCUPATIONAL MEDICINE
Poland
Address
Teresy Street 8
90 950 Lodz
UNIVERSITAET KARLSRUHE (TECHNISCHE HOCHSCHULE)
Germany
Address
Kaiserstrasse 12
76128 Karlsruhe