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Development of methods for predictive toxicity testing with reference to neurotoxic volatile chemicals.

Objective

The present proposal aims at providing innovative tools and more effective methods for mechanism-based risk assessment of neurotoxic compounds. A novel apparatus for the exposure of cell in culture to volatile agents will be developed. In addition selected cell types representing specific molecular neuronal targets for the toxic agents studied (carbon monoxide, hexane and styrene) will be used as in vitro experimental models. The final aim is to find and propose in vitro tests that could reduce the need for animal studies. By investigating a variety of possible end-points and using a multidisciplinary approach, the overall novelty of the project and the likelihood of a major advance in the field are greatly increased.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

KAROLINSKA INSTITUTE
Address
Nobels Vaeg, 13
171 77 Stockholm
Sweden

Participants (5)

FONDAZIONE SALVATORE MAUGERI - CLINICA DEL LAVORO E DELLA RIABILITAZIONE
Italy
Address
Via A. Ferrata 8
27100 Pavia
FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPE FELIPE
Spain
Address
4,Amadeo De Saboya 4
46010 Valencia
LEOPOLD-FRANZENS-UNIVERSITAET INNSBRUCK
Austria
Address
52,Christoph-probst-platz 1
6020 Innsbruck
THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN
Ireland
Address
Trinity College
2 Dublin
UNIVERSITA DEGLI STUDI DI PARMA
Italy
Address
Via Universita 12
43100 Parma