Objective
The goal of the proposal is to elucidate the effects of developmental exposure of animals to flame retardants Polybrominated Diphenyle Ethers (PBDE) on the central nervous system (CNS). Epidemiological studies indicate a marked increase of PBDE levels in breast milk. In contrast, effects of PBDEs on the developing CNS are largely unknown. Therefore, the aims of the proposal are: to assess several neurobehavioural endpoints after perinatal treatment of animals for characterization of of possible impairments; To relate neurobehavioral effects to electrophysiological effects in the different brain areas; To compare perinatal with adult exposure in order to examine if the developing CNS is particularly susceptible to PBDEs; To compare different animal species for generalization of the findings; and to characterize mechanisms of PBDE neural toxicity at cellular and molecular levels; to examine if exposure alters sexual differentiation of the brain. PBDE effects will be compared to PCB-induced effects.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
40225 DUESSELDORF
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.