Objective
The goal of the proposal is to elucidate the effects of developmental exposure of animals to flame retardants Polybrominated Diphenyle Ethers (PBDE) on the central nervous system (CNS). Epidemiological studies indicate a marked increase of PBDE levels in breast milk. In contrast, effects of PBDEs on the developing CNS are largely unknown. Therefore, the aims of the proposal are: to assess several neurobehavioural endpoints after perinatal treatment of animals for characterization of of possible impairments; To relate neurobehavioral effects to electrophysiological effects in the different brain areas; To compare perinatal with adult exposure in order to examine if the developing CNS is particularly susceptible to PBDEs; To compare different animal species for generalization of the findings; and to characterize mechanisms of PBDE neural toxicity at cellular and molecular levels; to examine if exposure alters sexual differentiation of the brain. PBDE effects will be compared to PCB-induced effects.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
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Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
40225 DUESSELDORF
Germany