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The impact of developmental exposure to weak (environmental) estrogens on the incidence of diseases in target organs later in life

Objective

The incidence of cancer is increasing steadily in tissues that are regulated by estrogens. It has been proposed that the increased cancer incidence but also fertility problems in wildlife and humans is caused by an increased exposure to environmental compounds that mimic endogenous estrogens. In the current project we will perform model studies to determine the potential impact of developmental exposure to weak estrogens on the incidence of diseases in the mammary gland, testis, prostate, ovary and brain. The project aims to improve current testing strategies, and provide molecular markers that can be used in clinical research to quantify the involvement of dietary and environmental estrogens in the ethnology of major human diseases.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

NETHERLANDS INSTITUTE FOR DEVELOPMENTAL BIOLOGY
Address
Uppsalalaan 8
3584 CT Utrecht
Netherlands

Participants (4)

COPENHAGEN UNIVERSITY HOSPITAL
Denmark
Address
Blegdamsvej 9
2100 Koepenhagen
JOHANNES GUTENBERG UNIVERSITAET MAINZ
Germany
Address
Staudinger Weg 7
55099 Mainz
KAROLINSKA INSTITUTE
Sweden
Address
Novum Huddinge Sjukhus
141 86 Huddinge
UTRECHT UNIVERSITY
Netherlands
Address
Sorbonnelaan 16
3584 CA Utrecht