Objective The partners have previously shown that a high frequency of chromosomal aberrations (CAs) in peripheral lymphocytes is predictive of increased cancer risk, regardless of smoking or occupational carcinogen exposure. The present multidisciplinary project aims at clarifying the reasons for these findings. Archived cell specimens of subjects earlier examined for cytogenesis biomarkers will be analysed for major genetic polymorphisms suspected to affect chromosome damage. These data will be used to reveal those Polymorphisms that modify the frequency of CAs and of sister chromatic exchanges (SCEs) and the cancer association of CAs. The existing cohorts will be re-examined to identify the types of CAs indicative of cancer risk and to re-evaluate if SCEs predict cancer. Two new European cohorts will be assembled, one to confirm the findings on CAs and SCEs and to study association with major cancer types, and another to see if cancer risk is predicted by lymphocyte micronucleus frequency. Fields of science medical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesgeneticschromosomes Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-4. - Key action Environment and Health Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator FINNISH INSTITUTE OF OCCUPATIONAL HEALTH Address 41 a,topeliuksenkatu 41 a 00250 Helsinki Finland See on map EU contribution € 0,00 Participants (12) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUTE OF EXPERIMENTAL MEDICINE - ACADEMY OF SCIENCES OF THE CZECH REPUBLIC Czechia EU contribution € 0,00 Address Videnska 1083 14220 Praha 4 See on map INSTITUTO NAZIONALE PER LA RICERCA SUL CANCRO Italy EU contribution € 0,00 Address Largo rosanna benzi 10 16132 Genova See on map INTERNATIONAL AGENCY FOR RESEARCH ON CANCER France EU contribution € 0,00 Address 150,cours albert thomas 150 69372 Lyon See on map JAGIELLONIAN UNIVERSITY Poland EU contribution € 0,00 Address Kopernika, 25 31501 Krakow See on map LUND UNIVERSITY Sweden EU contribution € 0,00 Address University hospital 221 85 Lund See on map NATIONAL INSTITUTE OF ONCOLOGY Hungary EU contribution € 0,00 Address Rath gyoergy 7-9 1122 Budapest See on map NATIONAL INSTITUTE OF PUBLIC HEALTH Czechia EU contribution € 0,00 Address 48,srobarova 48 100 42 Praha 10 See on map RADIATION AND NUCLEAR SAFETY AUTHORITY Finland EU contribution € 0,00 Address Laippatie 4 00880 Helsinki See on map STATE HEALTH INSTITUTE Slovakia EU contribution € 0,00 Address Cesta k. nemocnici 1 975 56 Banska bystrica See on map TELEMARK CENTRAL HOSPITAL Norway EU contribution € 0,00 Address Ulefossvn.55 3710 Skien See on map VILNIUS UNIVERSITY Lithuania EU contribution € 0,00 Address 3,universiteto 3 2734 Vilnius See on map VRIJE UNIVERSITEIT BRUSSEL Belgium EU contribution € 0,00 Address Pleinlaan 2 1050 Bruxelles See on map
