Cytogenetic biomarkers and human cancer risk

Objective

The partners have previously shown that a high frequency of chromosomal aberrations (CAs) in peripheral lymphocytes is predictive of increased cancer risk, regardless of smoking or occupational carcinogen exposure. The present multidisciplinary project aims at clarifying the reasons for these findings. Archived cell specimens of subjects earlier examined for cytogenesis biomarkers will be analysed for major genetic polymorphisms suspected to affect chromosome damage. These data will be used to reveal those Polymorphisms that modify the frequency of CAs and of sister chromatic exchanges (SCEs) and the cancer association of CAs. The existing cohorts will be re-examined to identify the types of CAs indicative of cancer risk and to re-evaluate if SCEs predict cancer. Two new European cohorts will be assembled, one to confirm the findings on CAs and SCEs and to study association with major cancer types, and another to see if cancer risk is predicted by lymphocyte micronucleus frequency.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-4. - Key action Environment and Health

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

FINNISH INSTITUTE OF OCCUPATIONAL HEALTH

Address

41 A,topeliuksenkatu 41 A
00250 Helsinki
Finland

Participants (12)

INSTITUTE OF EXPERIMENTAL MEDICINE - ACADEMY OF SCIENCES OF THE CZECH REPUBLIC

Czechia

Address

Videnska 1083
14220 Praha 4

INSTITUTO NAZIONALE PER LA RICERCA SUL CANCRO

Italy

Address

Largo Rosanna Benzi 10
16132 Genova

INTERNATIONAL AGENCY FOR RESEARCH ON CANCER

France

Address

150,Cours Albert Thomas 150
69372 Lyon

JAGIELLONIAN UNIVERSITY

Poland

Address

Kopernika, 25
31501 Krakow

LUND UNIVERSITY

Sweden

Address

University Hospital
221 85 Lund

NATIONAL INSTITUTE OF ONCOLOGY

Hungary

Address

Rath Gyoergy 7-9
1122 Budapest

NATIONAL INSTITUTE OF PUBLIC HEALTH

Czechia

Address

48,Srobarova 48
100 42 Praha 10

RADIATION AND NUCLEAR SAFETY AUTHORITY

Finland

Address

Laippatie 4
00880 Helsinki

STATE HEALTH INSTITUTE

Slovakia

Address

Cesta K. Nemocnici 1
975 56 Banska Bystrica

TELEMARK CENTRAL HOSPITAL

Norway

Address

Ulefossvn.55
3710 Skien

VILNIUS UNIVERSITY

Lithuania

Address

3,Universiteto 3
2734 Vilnius

VRIJE UNIVERSITEIT BRUSSEL

Belgium

Address

Pleinlaan 2
1050 Bruxelles