Objective
This proposal aims at identifying new biomarkers to improve the current approach for assessing the androgen disruption activity of chemicals (type flu amide) on testicular development and function. The objectives are
(I) to use a DNA micro array approach to identify among thousands of testicular genes those whose expression is altered in fatally flu amide treated rats and
(II) to delineate the potential role of the proteins encoded by these altered genes in the activities of germ cells, Sirloin and Lading cells. The project is divided in 5 work packages including that concerning the project coordination. The WP2 (DNA micro array preparation) and WP3 (tabular tissues from flu amide treated rats) are performed by the industrial partner. Once the altered genes are identified in WP2 and WP3, experiments based on the in vivo and in vitro expression of these genes and transfixion of these genes in testicular cell lines will delineate their potential role in germ cell (Spa, Sterol cell (WP5) and Lydia cell (WP6) specific activities. From these experiments, we expect to (I) identify key genes involved in testicular path physiology related to an endocrine disruption activity and (ii) provide through these relevant genes new fine biomarkers to assess the ant androgen potential of chemicals.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine physiology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69495 PIERRE-BENITE
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.