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Protection against allergy: study in rural environments

Objective

In animals substantial prevention of allergy can be achieved by inhalation of microbial products. It is unknown whether such findings can be brought forward to humans, but findings in farmers' children raised in environments rich in microbial matter suggest that these children constitute an ideal 'natural' model to study these relations in humans. Recent retrospective surveys clearly indicated that exposures must occur in pregnancy and the 1st Year of life to confer significant protection, resulting in very low prevalence's of asthma (0.8% vs. 11.8%), hay fever (0.8% vs. 16.0%) and atop (8.2% vs. 32.9%) as compared to non-exposed children. The project therefore focuses on early life exposures to indoor microbial matter in a prospective study design. A multidisciplinary approach is taken to study immunological and genetic mechanisms determining the strong protective effects, which will allow the development of novel preventive strategies.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH
Address
Lindwurmstrasse 4
80337 Muenchen
Germany

Participants (6)

AMT DER SALZBURGER LANDESREGIERUNG
Austria
Address
Muellner Haupstrasse 48
5020 Salzburg
NATIONAL PUBLIC HEALTH INSTITUTE
Finland
Address
4,Neulaniementie 4
70210 Kuopio
PHILIPPS UNIVERSITY MARBURG
Germany
Address
Baldingerstrasse 1
35033 Marburg
UNIVERSITAET BASEL
Switzerland
Address
49,Steinengraben 49
4051 Basel
UNIVERSITAETSKLINIKUM ULM
Germany
Address
Syrlinstrasse 38
89073 Ulm
UNIVERSITY OF ZURICH
Switzerland
Address
Steinwiesstrasse 75
8032 Zurich