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Protection against allergy: study in rural environments

Ziel

In animals substantial prevention of allergy can be achieved by inhalation of microbial products. It is unknown whether such findings can be brought forward to humans, but findings in farmers' children raised in environments rich in microbial matter suggest that these children constitute an ideal 'natural' model to study these relations in humans. Recent retrospective surveys clearly indicated that exposures must occur in pregnancy and the 1st Year of life to confer significant protection, resulting in very low prevalence's of asthma (0.8% vs. 11.8%), hay fever (0.8% vs. 16.0%) and atop (8.2% vs. 32.9%) as compared to non-exposed children. The project therefore focuses on early life exposures to indoor microbial matter in a prospective study design. A multidisciplinary approach is taken to study immunological and genetic mechanisms determining the strong protective effects, which will allow the development of novel preventive strategies.

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Koordinator

LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH
Adresse
Lindwurmstrasse 4
80337 Muenchen
Deutschland

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Beteiligte (6)

AMT DER SALZBURGER LANDESREGIERUNG
Österreich
Adresse
Muellner Haupstrasse 48
5020 Salzburg

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NATIONAL PUBLIC HEALTH INSTITUTE
Finnland
Adresse
4,neulaniementie 4
70210 Kuopio

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PHILIPPS UNIVERSITY MARBURG
Deutschland
Adresse
Baldingerstrasse 1
35033 Marburg

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UNIVERSITAET BASEL
Schweiz
Adresse
49,steinengraben 49
4051 Basel

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UNIVERSITAETSKLINIKUM ULM
Deutschland
Adresse
Syrlinstrasse 38
89073 Ulm

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UNIVERSITY OF ZURICH
Schweiz
Adresse
Steinwiesstrasse 75
8032 Zurich

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