Exposure - outcome relationships in male urogenital malformations with special reference to endocrine disrupters

Objective

There is a growing concern of a possible relationship between increasing trends inhale argental disorders in Europe and exposure to endocrine disrupters. Our aims to examine a hypothesis that fatal exposure to endocrine disrupters may contribute to the aetiology of argental disorders. The proposal is based on previous multinational cohort study of 5800 boys and mothers, in which a large amount of background data, hormonal information, and biological samples (blood, placentas, mother's milk) were collected. The samples will be analysed for putative endocrine disrupters, and exposure-outcome relationship will be analysed in a matched case-control study involving 215 infant boys detected to have argental disorder and 380 matched controls. Exposure information will also be related to information from mothers and to hormonal data. Data will be entered toad centralised database. Risk analysis of dioxins will be made.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-4. - Key action Environment and Health

Funding Scheme

Coordinator

Participants (3)