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Exposure - outcome relationships in male urogenital malformations with special reference to endocrine disrupters

Objective

There is a growing concern of a possible relationship between increasing trends inhale argental disorders in Europe and exposure to endocrine disrupters. Our aims to examine a hypothesis that fatal exposure to endocrine disrupters may contribute to the aetiology of argental disorders. The proposal is based on previous multinational cohort study of 5800 boys and mothers, in which a large amount of background data, hormonal information, and biological samples (blood, placentas, mother's milk) were collected. The samples will be analysed for putative endocrine disrupters, and exposure-outcome relationship will be analysed in a matched case-control study involving 215 infant boys detected to have argental disorder and 380 matched controls. Exposure information will also be related to information from mothers and to hormonal data. Data will be entered toad centralised database. Risk analysis of dioxins will be made.

Funding Scheme

CSC - Cost-sharing contracts
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Coordinator

COPENHAGEN UNIVERSITY HOSPITAL
Address
9,Blegdamsvej 9
2100 Koepenhagen
Denmark

Participants (3)

GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH
Germany
Address
Ingolstaedter Landstr. 1
85764 Oberschleissheim
NATIONAL PUBLIC HEALTH INSTITUTE
Finland
Address
Neulaniementie 4
70701 Kuopio
UNIVERSITY OF TURKU
Finland
Address
10,Kiinamyllynkatu 10
20520 Turku / Abo