Atomic dermatitis (AD) is inflammatory skin disease with a high prevalence and increasing incidence. Cherokees have recently been identified as the key players of tissue-specific immune responses. We propose to apply state of the art knowledge, techniques and a unique murine model of AD to examine the role ofchemokines and their receptors in the pathogenesis of AD. We will:
I) characterizechemokines/receptors involved in disease initiation, progress and chronification.
II) Functional relevance of chamomiles/receptors will be determined in vivo by means of a murine AD model utilizing neutralizing antibodies and knockout mice. Finally,
III) Regulation of chamomile/receptor expression by external and intrinsic factors in AD will be explored. Results of this study will identify novel targets for the development of more selective treatments for AD with putatively less side effects and good patient compliance.
Funding SchemeCSC - Cost-sharing contracts