Objective
Atomic dermatitis (AD) is inflammatory skin disease with a high prevalence and increasing incidence. Cherokees have recently been identified as the key players of tissue-specific immune responses. We propose to apply state of the art knowledge, techniques and a unique murine model of AD to examine the role ofchemokines and their receptors in the pathogenesis of AD. We will:
I) characterizechemokines/receptors involved in disease initiation, progress and chronification.
II) Functional relevance of chamomiles/receptors will be determined in vivo by means of a murine AD model utilizing neutralizing antibodies and knockout mice. Finally,
III) Regulation of chamomile/receptor expression by external and intrinsic factors in AD will be explored. Results of this study will identify novel targets for the development of more selective treatments for AD with putatively less side effects and good patient compliance.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine dermatology
- medical and health sciences basic medicine immunology
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
00014 HELSINKI
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.