Risk assessment of brominated flame-retardants as suspected endocrine disrupters for human and wildlife health

Objective

The project is an integrated approach of directed toxicological studies and exposure assessments to characterise the emerging human and wildlife health risks from brominates flame retardants (Bars) by endocrine disruption. The project consists of seven themes:
1) Selection of the BFR congeners by in vitro (receptor) assays covering a wide spectrum of endocrine effects;
2) Human hazard identification by studies in rats, including assessment of reproductive and immune function;
3) Aquatic wildlife hazard identification in zebra fish and flounder;
4) Human exposure assessment by measurement of actual levels and time trends in breast milk and human diets in Europe;
5) Aquatic ecosystem exposure assessment by measurement of levels in the aquatic food chain including top predators in polluted and reference sites in Europe;
6) Integrated risk assessment for humans and aquatic wildlife based on data from themes 1-5; and
7) Communication to policymakers, public and industry as basis for preventive action.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-4. - Key action Environment and Health

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

NATIONAL INSTITUTE OF PUBLIC HEALTH AND ENVIRONMENT

Address

Antonie Van Leeuwenhoeklaan 9
3720 BA Bilthoven
Netherlands

Participants (18)

GESELLSCHAFT ZUR FOERDERUNG DER LUFTHYGIENE UND SILIKOSEFORSCHUNG E.V.

Germany

Address

Auf'm Hennekamp 50
40225 Duesseldorf

INSTITUTE OF CHEMICAL TECHNOLOGY, PRAGUE

Czechia

Address

Technicka 3
166 28 Praha 6

KAROLINSKA INSTITUTE

Sweden

Address

Von Eulers Vag 3
171 77 Stockholm

MINISTRY OF TRANSPORT PUBLIC WORKS AND WATER MANAGEMENT

Netherlands

Address

Kortenaerkade 1
2500 EX Den Haag ('S-gravenhage)

NATIONAL VETERINARY INSTITUTE

Norway

Address

Ullevaalsveien 68
0033 Oslo

NETHERLANDS INSTITUTE FOR FISHERIES RESEARCH

Netherlands

Address

Haringkade 1
1970 AB Ijmuiden

NETHERLANDS INSTITUTE FOR SEA RESEARCH

Netherlands

Address

Landsdiep 4
1790 AB Den Burg

NORWEGIAN INSTITUTE OF PUBLIC HEALTH

Norway

Address

0403 Oslo

NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY

Norway

Address

Hogskoleringen 5
7491 Trondheim

STOCKHOLM UNIVERSITET

Sweden

Address

Svante Arrhenius Vaeg, 12
106 91 Stockholm

TECHNISCHE UNIVERSITAET KAISERSLAUTERN

Germany

Address

Erwin Schroedinger Strasse 46
67663 Kaiserslautern

UNIVERSITEIT VAN AMSTERDAM

Netherlands

Address

Nieuwe Achtergracht 166
1018 WV Amsterdam

UNIVERSITY OF SURREY

United Kingdom

Address

Guildford

UNIVERSITY OF UMEAA

Sweden

Address

Universitetsomradet, Naturvetarhuset, Kbc-building
901 57 Umeaa

UNIVERSITY OF WUERZBURG

Germany

Address

Versbacher Strasse 9
97078 Wuerzburg

UTRECHT UNIVERSITY

Netherlands

Address

Yalelaan 2
3584 CL Utrecht

Universitair Centrum Antwerpen - Universiteit Antwerpen

Belgium

Address

Groenenborgenlaan 171
2020 Anvers /Antwerpen

VRIJE UNIVERSITEIT AMSTERDAM - VERENIGING VOOR CHRISTELIJK WETENSCHAPPELIJK ONDERWIJS

Netherlands

Address

De Boelelaan 1115
1081 HV Amsterdam