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Risk assessment of brominated flame-retardants as suspected endocrine disrupters for human and wildlife health

Objective

The project is an integrated approach of directed toxicological studies and exposure assessments to characterise the emerging human and wildlife health risks from brominates flame retardants (Bars) by endocrine disruption. The project consists of seven themes:
1) Selection of the BFR congeners by in vitro (receptor) assays covering a wide spectrum of endocrine effects;
2) Human hazard identification by studies in rats, including assessment of reproductive and immune function;
3) Aquatic wildlife hazard identification in zebra fish and flounder;
4) Human exposure assessment by measurement of actual levels and time trends in breast milk and human diets in Europe;
5) Aquatic ecosystem exposure assessment by measurement of levels in the aquatic food chain including top predators in polluted and reference sites in Europe;
6) Integrated risk assessment for humans and aquatic wildlife based on data from themes 1-5; and
7) Communication to policymakers, public and industry as basis for preventive action.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

NATIONAL INSTITUTE OF PUBLIC HEALTH AND ENVIRONMENT
Address
Antonie Van Leeuwenhoeklaan 9
3720 BA Bilthoven
Netherlands

Participants (18)

GESELLSCHAFT ZUR FOERDERUNG DER LUFTHYGIENE UND SILIKOSEFORSCHUNG E.V.
Germany
Address
Auf'm Hennekamp 50
40225 Duesseldorf
INSTITUTE OF CHEMICAL TECHNOLOGY, PRAGUE
Czechia
Address
Technicka 3
166 28 Praha 6
KAROLINSKA INSTITUTE
Sweden
Address
Von Eulers Vag 3
171 77 Stockholm
MINISTRY OF TRANSPORT PUBLIC WORKS AND WATER MANAGEMENT
Netherlands
Address
Kortenaerkade 1
2500 EX Den Haag ('S-gravenhage)
NATIONAL VETERINARY INSTITUTE
Norway
Address
Ullevaalsveien 68
0033 Oslo
NETHERLANDS INSTITUTE FOR FISHERIES RESEARCH
Netherlands
Address
Haringkade 1
1970 AB Ijmuiden
NETHERLANDS INSTITUTE FOR SEA RESEARCH
Netherlands
Address
Landsdiep 4
1790 AB Den Burg
NORWEGIAN INSTITUTE OF PUBLIC HEALTH
Norway
Address

0403 Oslo
NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY
Norway
Address
Hogskoleringen 5
7491 Trondheim
STOCKHOLM UNIVERSITET
Sweden
Address
Svante Arrhenius Vaeg, 12
106 91 Stockholm
TECHNISCHE UNIVERSITAET KAISERSLAUTERN
Germany
Address
Erwin Schroedinger Strasse 46
67663 Kaiserslautern
UNIVERSITEIT VAN AMSTERDAM
Netherlands
Address
Nieuwe Achtergracht 166
1018 WV Amsterdam
UNIVERSITY OF SURREY
United Kingdom
Address

Guildford
UNIVERSITY OF UMEAA
Sweden
Address
Universitetsomradet, Naturvetarhuset, Kbc-building
901 57 Umeaa
UNIVERSITY OF WUERZBURG
Germany
Address
Versbacher Strasse 9
97078 Wuerzburg
UTRECHT UNIVERSITY
Netherlands
Address
Yalelaan 2
3584 CL Utrecht
Universitair Centrum Antwerpen - Universiteit Antwerpen
Belgium
Address
Groenenborgenlaan 171
2020 Anvers /Antwerpen
VRIJE UNIVERSITEIT AMSTERDAM - VERENIGING VOOR CHRISTELIJK WETENSCHAPPELIJK ONDERWIJS
Netherlands
Address
De Boelelaan 1115
1081 HV Amsterdam