Reliable models for the toxicological testing of hormonally active compounds are essential for the development of safety assessment programmes related to the exposure of animals and humans to endocrine disrupters (Ends). The objective of this project is to develop a transgenic mouse model for the characterization of environmental estrogens. This model will contain all the genetic elements that may provide a rapid, flexible, sensitive, economic and informative system for the toxicological testing and for the hazard identification/risk assessment of Ends. Moreover, from this model, reliable "in vitro" systems will be derived. A new estrogens regulated reporter system will also be constructed for its application to the study of low levels of hormones "in vitro". The economical relevance of our project is attested by the industrial participation.
Funding SchemeCSC - Cost-sharing contracts
171 77 Stockholm