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Development and implementation of new 'in vivo' and 'in vitro' systems for the characterisation of endocrine disruptors

Objective

Reliable models for the toxicological testing of hormonally active compounds are essential for the development of safety assessment programmes related to the exposure of animals and humans to endocrine disrupters (Ends). The objective of this project is to develop a transgenic mouse model for the characterization of environmental estrogens. This model will contain all the genetic elements that may provide a rapid, flexible, sensitive, economic and informative system for the toxicological testing and for the hazard identification/risk assessment of Ends. Moreover, from this model, reliable "in vitro" systems will be derived. A new estrogens regulated reporter system will also be constructed for its application to the study of low levels of hormones "in vitro". The economical relevance of our project is attested by the industrial participation.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

THE UNIVERSITY OF MILANO
Address
Via Festa Del Perdono 7
20122 Milano
Italy

Participants (3)

AZIENDA OSPEDALIERA "SPEDALI CIVILI" DI BRESCIA
Italy
Address
Piazzale Spedali Civili 1
25125 Brescia
KAROLINSKA INSTITUTE
Sweden
Address
Solnavagen 1
171 77 Stockholm
UNIVERSITY OF FRIBOURG
Switzerland
Address
Rte De Bonnesfontaines, 11
1700 Fribourg