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Environmental agent susceptibility assessment utilising existing and novel biomarkers as rapid non-invasive testing methods

Objective

ASYRING will improve information regarding the environmental levels of pollutants, their biological effects as measured with innovative tools to aquatic species and for mammalian risk assessment. It aims to develop and validate novel non-invasive methods for the detection of known and new biomarkers of endocrine disrupters. (Ends) directly in the mucus of aquatic species. Short/long term and low dose exposures to endocrine disrupting chemicals will be investigated both in aquatic species and mammals. In parallel, integrated testing in vitro protocols will permit a wider understanding and evaluation of effects and new instrumental analytical techniques will be developed and validated for easier and more complete detection of chemicals in water and biota. Quantitative structure-activity relationships (Tsars) for the prediction of chemicals able to elicit endocrine disruption and quantitative activity-activity relationships (Quarts) to extrapolate the response of different experimental models will be compared with test data developed in this project. The final aim will be to extend mathematical models to human toxicity.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

N/A

Participants (7)

BIOSENSE LABORATORIES A/S
Norway
Address
Thromohlensgt. 55
5008 Bergen
FORSCHUNGSVERBUND BERLIN E.V.
Germany
Address
Mueggelseedamm 310
12587 Berlin
LIVERPOOL JOHN MOORES UNIVERSITY
United Kingdom
Address
Byrom Street
L3 3AF Liverpool
MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH
Italy
Address
62,Via Eritrea 62
20157 Milano
NATIONAL RESEARCH COUNCIL OF ITALY
Italy
Address
Via Della Mornera 25
20147 Milano
UNIVERSITE DE MONS-HAINAUT.
Belgium
Address
Place Du Parc 20
Mons-bergen
UNIVERSITY OF BERGEN
Norway
Address
Thormohlensgt. 55
5008 Bergen