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Genetic markers and susceptibility to the effects of endocrine disruptors during mammalian testis development

Objective

Endocrine Disruptors (EDs) are a wide group of compounds, mainly environmental contaminants, that acting as endocrine deregulators could generate gene deregulation depending of the genetic background of the organisms. The reproductive systems have been considered a crucial target of the impact of EDs. Consequently, the analysis of the genetic effects of these compounds on developing gonads has repercussions on the effects upon the individuals and the progeny of future generations by genetic transmission. The proposed approaches will combine: animal models and cells, human exposure and new technologies based on microarrays of DNA and bio-informatic resources. The comparative results will help our understanding of endocrine disruption mechanisms, the genetic background driving to susceptibility to EDs and the testing of potential endocrine disrupters.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Address
Calle Serrano 117
Madrid
Spain

Participants (4)

GENETIX GROUP PLC
United Kingdom
Address
Queensway
BH25 5NN Bournemouth
NEOCODEX SL
Spain
Address
Edificio Acropolis Modulos 110-1 - Crta Nacional I
41007 Sevilla
UNIVERSITÀ DEGLI STUDI DI ROMA TOR VERGATA
Italy
Address
Via Di Tor Vergata 135
00133 Roma
WISE & MUNRO LEARNING RESEARCH
Netherlands
Address
8,Azaleastraat 85
2565 CD Den Haag