Endocrine Disruptors (EDs) are a wide group of compounds, mainly environmental contaminants, that acting as endocrine deregulators could generate gene deregulation depending of the genetic background of the organisms. The reproductive systems have been considered a crucial target of the impact of EDs. Consequently, the analysis of the genetic effects of these compounds on developing gonads has repercussions on the effects upon the individuals and the progeny of future generations by genetic transmission. The proposed approaches will combine: animal models and cells, human exposure and new technologies based on microarrays of DNA and bio-informatic resources. The comparative results will help our understanding of endocrine disruption mechanisms, the genetic background driving to susceptibility to EDs and the testing of potential endocrine disrupters.
Funding SchemeCSC - Cost-sharing contracts
BH25 5NN Bournemouth