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Quality of skin as a barrier to ultra-fine particles

Objective

Today' s population is increasingly exposed to ultrafine particles (<20 nm; e.g. Aerosil, TiO2) contained in body care and household products. Tape stripping studies and recent ion microscopy pilot studies revealed that such particles in, liposomal formulations penetrate the horny layer with large concentrations at the stratum granulosum and the possible risk of further penetration into vital tissue, especially for skin with an impaired barrier function. Here, apart from electron microscopy, high-resolution ion-microscopy techniques will be employed on skin cross-sections from biopsies (pig, human), which yield elemental maps of both the epidermis and dermis with ppm sensitivity for Ti or higher sensitivity with radiotracers (labelled TiO2) on pig skin. Pathways for percutaneous uptake and clearance will be studied. If such particles penetrate into the dermis, in-situ studies of tissue and in-vitro studies of particle-cell interactions follows.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITAET LEIPZIG
Address
Linnestrasse 5
04103 Leipzig
Germany

Participants (6)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Michel Ange 3
75794 Paris
INSTITUTO TECNOLOGICO E NUCLEAR
Portugal
Address
Estrada Nacional 10
2686-953 Sacavem
JAGIELLONIAN UNIVERSITY
Poland
Address
St..anna's Street 8
31 008 Krakow
THE HENRYK NIEWODNICZANSKI INSTITUTE OF NUCLEAR PHYSICS
Poland
Address
152,Radzikowskiego 152
31 342 Krakow
UNIVERSITE DE BORDEAUX I
France
Address
Cours De La Libération 351
33405 Talence
UNIVERSITY OF DEBRECEN
Hungary
Address
Nagyerdei Krt. 98
4012 Debrecen