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Engineering durable pathogen resistance in grapevine: a novel strategy for integrated disease management to overcome environmental impacts of pesticides

Objective

Grapevine is one of the major horticulture crops grown in temperate climates that is exposed to attacks from a variety of pathogens, including viruses. Viruses cause heavy crop losses, several million Euros per year, requiring the developing of novel approaches for disease control. We plan to achieve by expression of virus inactivating recombinant antibodies. This novel approach will generate biologically safe, virus-resistant plants. Based on their economic importance for viticulture, we will focus on the Nepoviruses GFLV and ArMV as well as on the Closteroviruses GLRaV-2 and GLRaV-3. Recombinant antibodies will be generated by phage display to specifically recognize and inactivate key viral proteins. This will reduce the use of environmentally unfriendly, undesirable chemical controls that are currently the only effective method for protecting vineyards from pathogen attack.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

AACHEN UNIVERSITY OF TECHNOLOGY
Address
Worringerweg 1
52074 Aachen
Germany

Participants (3)

DIENSTLEISTUNGSZENTRUM LAENDLICHER RAUM (DLR) RHEINPFALZ
Germany
Address
Breitenweg 71
67435 Neustadt(an Der Weinstra)
UNIVERSITA DEGLI STUDI DI BARI
Italy
Address
Via Amendola, 165/A
70126 Bari
VIVEIROS JORGE BOEHM PLANSEL LDA
Portugal
Address
Quinta De S. Jorge
7054-909 Montemor-o-novo