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Studies on the alimentary pathogensis of bse agent and natural scrapie in sheep and mice. implications for diagnosis and control.

Objective

This project will study the early pathogenesis of scrape and bovine spongiform encephalopathy (BSE) in sheep and mice, with emphasis on the uptake and accumulation of the prison protein (Prep) and infectivity in the gut-associated and peripheral lymphoid tissues and its relevance to neuroinvasion. The transport of Prep across the mucus of the gut and the interaction of disease-associated Prep with leukocytes, FRCS and nerves will be studied in novel systems such as isolated intestinal loops, surgical micro-infection, B-cell depleted sheep and transgenic mice over expressing ovine Prep. The consequences of accumulation of Prim lymphoid tissues for neuroinvasion and the development of a carrier state will be assessed. A better understanding of the early pathogenesis of scrape and BSE in sheep will contribute the detection of the pre-clinical disease and in developing future control and eradication strategies.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

NORWEGIAN SCHOOL OF VETERINARY SCIENCE
Address
Ullevaalsveien 72
0033 Oslo
Norway

Participants (3)

DEPARTMENT FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS
United Kingdom
Address
Woodham Lane, New Haw
KT15 3NB Addlestone
FRIEDRICH-LOEFLER INSTITUTE FEDERAL RESEARCH INSTITUT FOR ANIMAL HEALTH
Germany
Address
Boddenblick 5 A
17498 Insel Riems
ID LELYSTAD - INSTITUTE FOR ANIMAL HEALTH AND SCIENCE
Netherlands
Address
Edelhertweg 15
8219 PH Lelystad