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Evaluation of the possible transmission of prions (scrapie and bse) to different fish species

Objective

The nature of the transmissible agent of spongiform encephalopathies is thought to be the pathological form of the prion protein that can change the cellular form to a pathological one, also if it is orally ingested. Fish farming is becoming a very important industry. All farmed fish receive commercial food containing 40-55% protein. Animal proteins may also be present and potential occurrence of the pathological protein cannot be excluded. Since studies on the infectivity transmission in fish are very scanty, two lines of research are proposed:
l) TSE pathogenesis concerning fish as targets and/or vectors for disease;
2) identification of PrP and PrP-like proteins in fish genome.

The second line of the research is sustained by the reason that PrP gene in fish is not yet identified and the infectivity is only possible if the cellular protein is present and can change itself onto the pathological form.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CENTRE FOR RESEARCH AND TECHNOLOGY HELLAS
Address
Charilaou 6Th Km - Thermi Road
57001 Thermi
Greece

Participants (3)

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
6,Eduardo Cabello 6
36208 Vigo
NORWEGIAN SCHOOL OF VETERINARY SCIENCE
Norway
Address
Ullevaalsveien 72
Oslo
THE UNIVERSITY OF MILANO
Italy
Address
Via Festa Del Perdono 7
20122 Milano