Objective
The aim of the proposal is to identify potential therapeutic targets at the pre-clinical stages of transmissible spongiform encephalopathies (TSE). Studies will demonstrate and characterize the roles of dendrite cells (Daces) in the propagation at TSE agents (prisons) to the nervous system. Daces are involved at multiple levels of the infectious process, and their properties and functions might be manipulated. The following steps will be analysed:
- Penetration through the gut epithelium
- Accumulation in the associated-associated lymphoid tissue - Spreading to other lymphoid organs
- Factors of prison propagation (complement, receptors and receptors)
- Spreading from lymphoid structures to the nervous system The in vivo research may not be performed on naturally infected subjects, and must use a relevant experimental model, i.e. a standard oral inoculation protocol with well-defined mouse experimental scrape strains. Finally, certain studies will require in vitro analyses, especially those aimed at identifying molecular interactions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75571 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.