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Passage from intestine to brain: assessing the role of dendritic cells in capturing, expanding and disseminating prions

Objective

The aim of the proposal is to identify potential therapeutic targets at the pre-clinical stages of transmissible spongiform encephalopathies (TSE). Studies will demonstrate and characterize the roles of dendrite cells (Daces) in the propagation at TSE agents (prisons) to the nervous system. Daces are involved at multiple levels of the infectious process, and their properties and functions might be manipulated. The following steps will be analysed:
- Penetration through the gut epithelium
- Accumulation in the associated-associated lymphoid tissue - Spreading to other lymphoid organs
- Factors of prison propagation (complement, receptors and receptors)
- Spreading from lymphoid structures to the nervous system The in vivo research may not be performed on naturally infected subjects, and must use a relevant experimental model, i.e. a standard oral inoculation protocol with well-defined mouse experimental scrape strains. Finally, certain studies will require in vitro analyses, especially those aimed at identifying molecular interactions.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Hopital Saint-antoine - Batiment Kourilsky - Rue D
75571 Paris
France

Participants (7)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Cea-grenoble/dbms/ich, 17 Rue Des Martyrs
38054 Grenoble
Institute for Animal Health
United Kingdom
Address
Compton Laboratory Compton
RG16 0NN Newbury
Medical Research Council (MRC)
United Kingdom
Address
20 Park Crescent
W1N 4AL London
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
South Parks Road
OX1 3RE Oxford
THE NETHERLANDS CANCER INSTITUTE/ANTONI VAN LEEUWENHOEK HOSPITAL
Netherlands
Address
121,Plesmanlaan 121
1066 CX Amsterdam
UNIVERSITE DE LIEGE*ULG
Belgium
Address
Place Du 20 Aout 7
4000 Liege
UNIVERSITE PIERRE ET MARIE CURIE - PARIS VI
France
Address
Hopital Saint-antoine - Batiment Kourilsky - Rue D
75571 Paris