Passage from intestine to brain: assessing the role of dendritic cells in capturing, expanding and disseminating prions

Objective

The aim of the proposal is to identify potential therapeutic targets at the pre-clinical stages of transmissible spongiform encephalopathies (TSE). Studies will demonstrate and characterize the roles of dendrite cells (Daces) in the propagation at TSE agents (prisons) to the nervous system. Daces are involved at multiple levels of the infectious process, and their properties and functions might be manipulated. The following steps will be analysed:
- Penetration through the gut epithelium
- Accumulation in the associated-associated lymphoid tissue - Spreading to other lymphoid organs
- Factors of prison propagation (complement, receptors and receptors)
- Spreading from lymphoid structures to the nervous system The in vivo research may not be performed on naturally infected subjects, and must use a relevant experimental model, i.e. a standard oral inoculation protocol with well-defined mouse experimental scrape strains. Finally, certain studies will require in vitro analyses, especially those aimed at identifying molecular interactions.

Fields of science

• natural sciences › biological sciences › neurobiology

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-5. - Key action Sustainable Agriculture, Fisheries and Forestry

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Address

Hopital Saint-antoine - Batiment Kourilsky - Rue D
75571 Paris
France

Participants (7)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

Address

Cea-grenoble/dbms/ich, 17 Rue Des Martyrs
38054 Grenoble

Institute for Animal Health

United Kingdom

Address

Compton Laboratory Compton
RG16 0NN Newbury

Medical Research Council (MRC)

United Kingdom

Address

20 Park Crescent
W1N 4AL London

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

Address

South Parks Road
OX1 3RE Oxford

THE NETHERLANDS CANCER INSTITUTE/ANTONI VAN LEEUWENHOEK HOSPITAL

Netherlands

Address

121,plesmanlaan 121
1066 CX Amsterdam

UNIVERSITE DE LIEGE*ULG

Belgium

Address

Place Du 20 Aout 7
4000 Liege

UNIVERSITE PIERRE ET MARIE CURIE - PARIS VI

France

Address

Hopital Saint-antoine - Batiment Kourilsky - Rue D
75571 Paris