Objective
The age-related decline in endocrine function plays an important role in many of the changes in body composition and brain function that form part of the aging process. We propose to carry out studies in animals investigating how synthetic growth hormone secretagogues (GHS) act to improve body composition and brain function. Electrophysiological and neuroanatomical studies will determine how GHS interact with the brain pathways controlling growth hormone secretion, appetite and metabolism. Chronic GHS exposure will result in a new equilibrium of endocrine and CNS activity - we will study the consequences of long-term GHS exposure on hypothalamic gene expression and body composition. Studies of GHS action in animals with deletions in specific genes will identify the key sites of action of these compounds. Studies in obese diabetic animals (i.e. with symptoms of syndrome X) will include effects of GHS agonists and antagonists on the progression of the disease. Finally, since GHS increase circulating levels of insulin-like growth factors, we will determine the effects of GHS in the central IGF system, that has a protective role against neurodegeneration
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 3EG Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.