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Interactions between oxidative stress and the activation of mitogenic signalling in alzheimer's disease

Objective

Alzheimer's disease (AD), the leading cause of dementia in the elderly, places an increasing medical, social and economic burden on the European society. Neither treatment nor possibilities to prevent or delay the onset of the disease are available. The present multidisciplinary approach to be conducted as a multicoated study of eight groups on a European scale combines expertise in molecular biology, genetics, neurochemistry, neuromorphology, neuropharmacology, neurophysiology and behavioural biology. Interactions between oxidative stress as a major driving force of degeneration and the activation of mitogenic signalling as a critical trigger of neurodegeneration in AD modified by interactions and epistemic effects of AD-related genes will be studied. Research will be based on new models of the disease that allow to analyse the genetic, molecular and cellular mechanisms underplaying neurodegeneration, to identify molecular switches that critically determine the fate of a neuron after injury and to test potentially protective strategies. Aiming at the definition and design of a future rational and effective prevention and/or treatment of AD, anticipated deliverables will contribute to an improvement of the quality of life of the aging population.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITAET LEIPZIG
Address
Ritterstrasse 26
PF 100920 Leipzig
Germany

Participants (8)

CENTRUM BADAN MOLEKULARNYCH I MAKROMOLEKULARNYCH POLSKIEJ AKADEMII NAUK
Poland
Address
112,Sienkiewicza 112
90 363 Lodz
INTERNATIONAL UNIVERSITY OF CATALONIA
Spain
Address
Immaculada 22
08017 Barcelona
KAROLINSKA INSTITUTE
Sweden
Address
Novum, Kfc Plan 4
141 86 Stockholm
RUHR-UNIVERSITY BOCHUM
Germany
Address
Universitaetsstrasse 150
44780 Bochum
UNIVERSITY OF FLORENCE
Italy
Address
Piazza San Marco 4
50121 Firenze
UNIVERSITY OF KUOPIO
Finland
Address
Savilahdentie 9
1627 Kuopio
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
Address

NE1 7RU Newcastle Upon Tyne
WEIZMANN INSTITUTE OF SCIENCE
Israel
Address
Herzel Street 2
P.O.Box 26 Rehovot