Objective
Alzheimer's disease (AD), the leading cause of dementia in the elderly, places an increasing medical, social and economic burden on the European society. Neither treatment nor possibilities to prevent or delay the onset of the disease are available. The present multidisciplinary approach to be conducted as a multicoated study of eight groups on a European scale combines expertise in molecular biology, genetics, neurochemistry, neuromorphology, neuropharmacology, neurophysiology and behavioural biology. Interactions between oxidative stress as a major driving force of degeneration and the activation of mitogenic signalling as a critical trigger of neurodegeneration in AD modified by interactions and epistemic effects of AD-related genes will be studied. Research will be based on new models of the disease that allow to analyse the genetic, molecular and cellular mechanisms underplaying neurodegeneration, to identify molecular switches that critically determine the fate of a neuron after injury and to test potentially protective strategies. Aiming at the definition and design of a future rational and effective prevention and/or treatment of AD, anticipated deliverables will contribute to an improvement of the quality of life of the aging population.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences genetics
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PF 100920 LEIPZIG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.