Alzheimer's disease (AD), the leading cause of dementia in the elderly, places an increasing medical, social and economic burden on the European society. Neither treatment nor possibilities to prevent or delay the onset of the disease are available. The present multidisciplinary approach to be conducted as a multicoated study of eight groups on a European scale combines expertise in molecular biology, genetics, neurochemistry, neuromorphology, neuropharmacology, neurophysiology and behavioural biology. Interactions between oxidative stress as a major driving force of degeneration and the activation of mitogenic signalling as a critical trigger of neurodegeneration in AD modified by interactions and epistemic effects of AD-related genes will be studied. Research will be based on new models of the disease that allow to analyse the genetic, molecular and cellular mechanisms underplaying neurodegeneration, to identify molecular switches that critically determine the fate of a neuron after injury and to test potentially protective strategies. Aiming at the definition and design of a future rational and effective prevention and/or treatment of AD, anticipated deliverables will contribute to an improvement of the quality of life of the aging population.
Funding SchemeCSC - Cost-sharing contracts
90 363 Lodz
141 86 Stockholm
NE1 7RU Newcastle Upon Tyne