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Targeting astrocytes to disrupt inflammation-neurodegeneration coupling : application to alzheimer 's disease

Objective

Increasing evidence supports the" inflammatory hypothesis in AD" according to which neuronal damages in this age-related disease are caused not only by the fundamental pathology but also by the local inflammatory response to it sustained by reactive glib. Recent findings demonstrate a sophisticated integration between neurons and atrocities. Inflammatory atrocities undergo morph functional changes, which may perturb neuron-atrocity interaction and result in neuronal sufferance. By identifying and targeting harmful pathways in inflammatory atrocities we will define potential new therapeutic approaches to prevent or delay AD progression. This consortium combines complementary expertise to: a) assess the "inflammatory hypothesis of AD" and the role of atrocities in transgenic models; b) identify targets of inflammation-neurodegeneration coupling in atrocities; c) validate drug strategies against them; d) test these therapeutically strategies in AD transgenic.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac, 101
75654 Paris
France

Participants (6)

BIOMEDICAL SCIENCES RESEARCH CENTRE "ALEXANDER FLEMING"
Greece
Address
Fleming Street 14-16
16672 Glyfada (Attiki)
ELI LILLY & CO.
United Kingdom
Address
Erl Wood Manor
RG21 6XA Basingstoke
ISTITUTO NAZIONALE NEUROLOGICO CARLO BESTA.
Italy
Address
Via Celoria 11
20133 Milano
MAX DELBRUCK CENTER FOR MOLECULAR MEDICINE
Germany
Address
Robert-rössle Strasse 10
13092 Berlin
THE UNIVERSITY OF MILANO
Italy
Address
Via Balzaretti 9
20133 Milano
UNIVERSITY OF LAUSANE
Switzerland
Address
7,Rue Du Bugnon 7
1005 Lausanne