Targeting astrocytes to disrupt inflammation-neurodegeneration coupling : application to alzheimer 's disease

Objective

Increasing evidence supports the" inflammatory hypothesis in AD" according to which neuronal damages in this age-related disease are caused not only by the fundamental pathology but also by the local inflammatory response to it sustained by reactive glib. Recent findings demonstrate a sophisticated integration between neurons and atrocities. Inflammatory atrocities undergo morph functional changes, which may perturb neuron-atrocity interaction and result in neuronal sufferance. By identifying and targeting harmful pathways in inflammatory atrocities we will define potential new therapeutic approaches to prevent or delay AD progression. This consortium combines complementary expertise to: a) assess the "inflammatory hypothesis of AD" and the role of atrocities in transgenic models; b) identify targets of inflammation-neurodegeneration coupling in atrocities; c) validate drug strategies against them; d) test these therapeutically strategies in AD transgenic.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-6. - Key action The Ageing Population and Disabilities

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Address

Rue De Tolbiac, 101
75654 Paris
France

Participants (6)

BIOMEDICAL SCIENCES RESEARCH CENTRE "ALEXANDER FLEMING"

Greece

Address

Fleming Street 14-16
16672 Glyfada (Attiki)

ELI LILLY & CO.

United Kingdom

Address

Erl Wood Manor
RG21 6XA Basingstoke

ISTITUTO NAZIONALE NEUROLOGICO CARLO BESTA.

Italy

Address

Via Celoria 11
20133 Milano

MAX DELBRUCK CENTER FOR MOLECULAR MEDICINE

Germany

Address

Robert-rössle Strasse 10
13092 Berlin

THE UNIVERSITY OF MILANO

Italy

Address

Via Balzaretti 9
20133 Milano

UNIVERSITY OF LAUSANE

Switzerland

Address

7,Rue Du Bugnon 7
1005 Lausanne