Objective
Cerebral ischaemia is the third leading cause of death in the western world and present there remains no effective treatment for this pathological condition. Activation of cannabinoid (CB) receptors has been show to protect the rat brain against ischaemic insult. In addition cannabinoid receptor agonists have been shown to influence the production of the pro-inflammatory cytokine interleukin-1 (IL-1), inhibition of which has also been demonstrated to reduce the amount of neuronal damage following an ischaemic insult.
The aims of this project are to characterise the effects of cannabinoid agonists on neuronal cell death caused by permanent middle cerebral artery occlusion in the rat and to determine the receptors involved by using antagonists specific to either CB1 or CB2 receptors. The project will also investigate the time window of efficacy of these compounds, and determine the role of IL-1 in the cannabinoid-mediated effect by investigating the influence of the cannabinoid ligands on expression of IL-1/IL-1 receptor antagonist following an experimental ischaemic episode. The results of this project will provide a greater light into the mechanisms behind the neuroprotective effects of cannabinoids and clarify theu relationship to IL-1. Furthermore they will provide a foundation on which to build a drug discovery strategy for the identification of new pharmacological treatments of stroke.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences basic medicine neurology stroke
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
20132 MILANO
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.