Objective
Reperfusion/reperfusion injury is a well-known feature of acute/chronic renal dysfunction, known as acute renal failure (ARF), with 1-5% of hospitalised patients being affected. This is a major social economic problem of the ageing population and patients receiving kidney transplantation (cold schema), a demand increasing with age. ARF is associated with cell death by apoptosis or necrosis. Currently we do not know the impact of initiating and/or interrelated events during the onset and progression of ARF. It is imperative to characterize a sequence of events that links primary damaging components such as an unbalanced NO/O>2 - and/or xanthenes/adenosine ratio to an end stage injury. 4 groups that are recognized for cutting edge science will carry experiments out in-vivo and in-vitro using rodent material. The outcome of the project will be the establishment of an early index of cell death with the opportunity to intervene pharmacologically, thereby preventing progression of cell injury once initiated. The application of such newly established prognostic parameters to human subjects would serve to predict the severity of renal injury inhuman and open avenues for novel therapeutic interventions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08036 BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.