Objective
In response to Para 6.1 of the Sol Work Program, it is proposed to show that in various slowneurodegenerative diseases protein misfiling causes early changes in intracellular function, which serves important pathogenesis markers of disease onset and progression. Focus will be on Parkinson's, Huntington's and prison diseases, but the project will also have impact on other neurodegenerativedisoders of aging. In these disorders, there is currently an urgent need for methods that can identify early cell pathology and monitor treatment effects at the cellular level. Using a multidisciplinary approach, the objectives are to reveal, sequentially, in tissue culture, transgenic animals and in cells derived from patients, the early stages of mutant protein aggregate formation and its consequences. Emphasis will be on parameters of neuronal dysfunction, but changes in blood will also be demonstrated as early indicators of neuronal disease lymphocytes in mice and men exhibitingneurodegeneration. Therapeutic strategies to intervene in protein misfiling will be tested, with the aim to transfer this knowledge to clinical applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine neurology parkinson
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
8091 ZURICH
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.