Objective
Interendothelial adherents junctions play a crucial role in the development and maintenance of blood vessel integrity. Null mutation of the endothelial specific VE-adhering gene leads to impairment of vascular remodelling and endothelial survival, which is in part due to the loss of VEGF function as a survival factor in these instants. As it was shown that VE-adhering forms complexes with the VEGF receptor 2, in this project we will investigate the significance of VE-adhering in regulating VEGF function and which role beta-catena plays in this process. In adulation, since VE-adhering is an important determinant of contact inhibition of cell growth in the endothelium, the signalling processes at the basis of this activity will be studied. In order to address these questions endothelial cells cultured from VE adhering deficient mice will be used as a model for transfixion of various VE-adhering mutants in an endothelial background. Mutant proteins will be designed to alter either the binding or the detachment of beta-catena from VE-adhering. Furthermore the involvernent of the p120^ctn binding site and the significance of the extra cellular domain of VE-adhering will be investigated. In a second step, the beta-catena gene will be inactivated in endothelial cells specifically a Crew-Lox approach in vivo and the animal phenotype will be studied.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics mutation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
20157 MILANO
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.