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Functional genomics and proteomics in human molecular gerontology and geriatrics (development of ad hoc microarray, diagnostic applications and molecular screening) - (functionage)

Objective

Human gerontology is entering the post-genomic era. We will clarify how genes associated with ageing affect the process of successful (longevity without overt diseases) and unsuccessful ageing (proinflammatory status, age-related diseases, disabilities) by applying advanced functional genomic and polemics on complementary in vitro models of human ageing, and on cells from centenarians and patients struck by major age-related diseases. With an SME we will develop and exploit a reliable multi-functional µ-array 'Seneschal' suitable for molecular gerontology in vivo and in vitro, and for diagnostic in geriatrics, to evaluate the pro-inflammatory status of patients, particularly those at high risk for impending disability, and their morbidity and chance for survival after stressful conditions (surgical operations). Moreover Seneschals will be commercialised for helping the development of novel cosmeceuticals/anti-ageing drugs.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

FACULTES UNIVERSITAIRES NOTRE-DAME DE LA PAIX DE NAMUR
Address
61,Rue De Bruxelles 61
5000 Namur / Namen
Belgium

Participants (4)

EPPENDORF ARRAY TECHNOLOGIES S.A.
Belgium
Address
Rue Du Seminaire 22
5000 Namur / Namen
NATIONAL HELLENIC RESEARCH FOUNDATION
Greece
Address
48,Vas. Constantinou Avenue 48
11635 Athens
UNIVERSITY OF AARHUS
Denmark
Address
10C,c.f. Mollers Alle, Building 130
8000 Aarhus C
UNIVERSITY OF BOLOGNA
Italy
Address
Via Tolara Di Sopra 50
40064 Ozzano Dell Emilia