Functional genomics and proteomics in human molecular gerontology and geriatrics (development of ad hoc microarray, diagnostic applications and molecular screening) - (functionage)

Objective

Human gerontology is entering the post-genomic era. We will clarify how genes associated with ageing affect the process of successful (longevity without overt diseases) and unsuccessful ageing (proinflammatory status, age-related diseases, disabilities) by applying advanced functional genomic and polemics on complementary in vitro models of human ageing, and on cells from centenarians and patients struck by major age-related diseases. With an SME we will develop and exploit a reliable multi-functional µ-array 'Seneschal' suitable for molecular gerontology in vivo and in vitro, and for diagnostic in geriatrics, to evaluate the pro-inflammatory status of patients, particularly those at high risk for impending disability, and their morbidity and chance for survival after stressful conditions (surgical operations). Moreover Seneschals will be commercialised for helping the development of novel cosmeceuticals/anti-ageing drugs.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-6. - Key action The Ageing Population and Disabilities

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

FACULTES UNIVERSITAIRES NOTRE-DAME DE LA PAIX DE NAMUR

Address

61,Rue De Bruxelles 61
5000 Namur / Namen
Belgium

Participants (4)

EPPENDORF ARRAY TECHNOLOGIES S.A.

Belgium

Address

Rue Du Seminaire 22
5000 Namur / Namen

NATIONAL HELLENIC RESEARCH FOUNDATION

Greece

Address

48,Vas. Constantinou Avenue 48
11635 Athens

UNIVERSITY OF AARHUS

Denmark

Address

10C,c.f. Mollers Alle, Building 130
8000 Aarhus C

UNIVERSITY OF BOLOGNA

Italy

Address

Via Tolara Di Sopra 50
40064 Ozzano Dell Emilia