Human gerontology is entering the post-genomic era. We will clarify how genes associated with ageing affect the process of successful (longevity without overt diseases) and unsuccessful ageing (proinflammatory status, age-related diseases, disabilities) by applying advanced functional genomic and polemics on complementary in vitro models of human ageing, and on cells from centenarians and patients struck by major age-related diseases. With an SME we will develop and exploit a reliable multi-functional µ-array 'Seneschal' suitable for molecular gerontology in vivo and in vitro, and for diagnostic in geriatrics, to evaluate the pro-inflammatory status of patients, particularly those at high risk for impending disability, and their morbidity and chance for survival after stressful conditions (surgical operations). Moreover Seneschals will be commercialised for helping the development of novel cosmeceuticals/anti-ageing drugs.
Funding SchemeCSC - Cost-sharing contracts
5000 Namur / Namen
8000 Aarhus C
40064 Ozzano Dell Emilia