Objective
Multipotent neural progenitor cells have an unlimited capacity for self-renewal and can differentiate into various cell types. They may constitute a source of donor tissue for cell replacement therapies in neurological disorders. Embryonic progenitors can be expanded and differentiated in vitro, but survival after transplantation is poor. We aim to increase the proliferation rate, dopaminergic. Differentiation and survival of rat, and subsequently human, midbrain progenitors in vitro and after transplantation in vivo. This will be achieved by treatment with a capsize inhibitor and a lipid per oxidation inhibitor at different time points in vitro and during the transplantation procedure. Cells will be transplanted into a rat Parkinson model and analysed functionally and immunohistochemically. Recent findings indicate that pluripotent stem cells also reside in the adult brain. There is evidence from a Swedish group that adult epidermal stem cells repopulate the substantial Ingra, but these cells need to be further characterised in vivo. Adult rodent epidermal stem cells will be analysed after transplantation with respect to their migratory behaviour and differentiation potential (egg transmitter phenotype and detailed morphology) to assess their possible use for neural grafting. Increased knowledge about neural stem cells should help turn neural grafting from a highly experimental procedure into a clinically useful treatment for a large number of patients with intractable neurological disorders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences basic medicine neurology parkinson
- medical and health sciences clinical medicine transplantation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.