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Content archived on 2024-05-27

Establishment of a cell line and dna bank for genetic risk assessment and post transplant monitoring of complications following stem cell transplantation

Objective

Allergenic stem cell transplantation (SCT) remains the ultimate treatment for patients with lymphoproliferative and haematological disorders. Genetic differences, including transplantation antigens and cytokine gene polymorphisms, between patient and donor constitute genetic risk in SCT. Success of SCT relies on an accurate assessment of genetic risk factors in order to improve outcome. Genetic risk factors will be assessed by the use of an immortalised cell and DNA bank where outcome of the transplant is known. We aim to pool resources and establish a biological collection of fully genotypic ally characterised patient and donor immortalised cells for both in vitro patient monitoring post transplant and as a constant supply of DNA for genetic risk assessment; thus creating a unique and important European collection for use within the transplant community.

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Topic(s)

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Funding Scheme

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Coordinator

UNIVERSITY OF NEWCASTLE UPON TYNE
EU contribution
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Address
Queen Victoria Road Royal Victoria Infirmary
NE1 7RU NEWCASTLE UPON TYNE
United Kingdom

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Total cost

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Participants (7)

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