Determination of macromolecular crystal structures: integrated, automated and user-friendly approaches

Objective

X-ray crystallography continues to expand very rapidly and there are 100s of laboratories in academia and industry. This expansion will increase in response to genome based structural programmes. This proposal provides the growing community (often relatively inexperienced) with the crystallographic tools to meet the technically advanced demands of modern structural biology. The aim is to bring together major European crystallographic software groups to design, implement and support a framework for computational crystallography - namely, data processing, phase determination, refinement, validation and deposition of structural data. Twill address the problems often present in crystals with very large cells, complex assembly or unstable contents and lattice defects. It will involve the development of software for high throughput structure solution. This is an urgent requirement to handle the expected output of the genome projects.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-14. - Support for research infrastructures

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF YORK

Address

University Road
YO1 5DD York
United Kingdom

Participants (8)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

Address

Avenue De La Terrasse 14
91198 Gif-sur-yvette

COUNCIL FOR THE CENTRAL LABORATORY OF THE RESEARCH COUNCILS

United Kingdom

Address

Keckwick Lane
WA4 4AD Warrington

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

Address

Meyerhofstrasse 1
Heidelberg

GEORG-AUGUST-UNIVERSITY GOETTINGEN

Germany

Address

Wilhelmsplatz 1
37073 Goettingen

GLOBAL PHASING LIMITED

United Kingdom

Address

Station Road 38
CB1 2JH Cambridge

MRC Laboratory of Molecular Biology

United Kingdom

Address

Hills Road
CB2 2QH Cambridge

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

Address

6500 GL Nijmegen

THE NETHERLANDS CANCER INSTITUTE/ANTONI VAN LEEUWENHOEK HOSPITAL

Netherlands

Address

121,Plesmanlaan 121
1066 CX Amsterdam