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Determination of macromolecular crystal structures: integrated, automated and user-friendly approaches

Objective

X-ray crystallography continues to expand very rapidly and there are 100s of laboratories in academia and industry. This expansion will increase in response to genome based structural programmes. This proposal provides the growing community (often relatively inexperienced) with the crystallographic tools to meet the technically advanced demands of modern structural biology. The aim is to bring together major European crystallographic software groups to design, implement and support a framework for computational crystallography - namely, data processing, phase determination, refinement, validation and deposition of structural data. Twill address the problems often present in crystals with very large cells, complex assembly or unstable contents and lattice defects. It will involve the development of software for high throughput structure solution. This is an urgent requirement to handle the expected output of the genome projects.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF YORK
Address
University Road
YO1 5DD York
United Kingdom

Participants (8)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Avenue De La Terrasse 14
91198 Gif-sur-yvette
COUNCIL FOR THE CENTRAL LABORATORY OF THE RESEARCH COUNCILS
United Kingdom
Address
Keckwick Lane
WA4 4AD Warrington
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Address
Meyerhofstrasse 1
Heidelberg
GEORG-AUGUST-UNIVERSITY GOETTINGEN
Germany
Address
Wilhelmsplatz 1
37073 Goettingen
GLOBAL PHASING LIMITED
United Kingdom
Address
Station Road 38
CB1 2JH Cambridge
MRC Laboratory of Molecular Biology
United Kingdom
Address
Hills Road
CB2 2QH Cambridge
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
Address

6500 GL Nijmegen
THE NETHERLANDS CANCER INSTITUTE/ANTONI VAN LEEUWENHOEK HOSPITAL
Netherlands
Address
121,Plesmanlaan 121
1066 CX Amsterdam