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Pilot-study for a human epigenome project

Objective

For an elucidation of complex human disease, all available sources of biological information are required. Biological information sources are DNA, mRNA, proteins, metabolic networks and epigenetic information in the form of chromatin structure and DNA-methylamine. DNA-methylamine is tissue specific and correlates with gene- expression, hence being a likely contributor to pathogenesis. The pilot-project proposed will demonstrate the methylamine blueprint of two different human tissues for a selected 4 Mb genomic region, the Major Histocompatibility Complex (MHC) by genomic sequencing. The MHC is the most polymorphism genomic region known, the densest in genes and displays association with a number of diseases. In addition, correlations between heliotypes associated with Psoriasis, an MHC-linked disease and methylamine epigenotypes will establish reproducible inter-individual, disease related variation of methylamine patterns.

Call for proposal

Data not available

Coordinator

GENOME RESEARCH LTD.
Address
The Wellcome Trust Genome Campus Hinxton
CB10 1SA Saffron Walden
United Kingdom

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Links

Participants (1)

EPIGENOMICS AG
Germany
Address
Kastanienallee 24
Berlin

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