Objective For an elucidation of complex human disease, all available sources of biological information are required. Biological information sources are DNA, mRNA, proteins, metabolic networks and epigenetic information in the form of chromatin structure and DNA-methylamine. DNA-methylamine is tissue specific and correlates with gene- expression, hence being a likely contributor to pathogenesis. The pilot-project proposed will demonstrate the methylamine blueprint of two different human tissues for a selected 4 Mb genomic region, the Major Histocompatibility Complex (MHC) by genomic sequencing. The MHC is the most polymorphism genomic region known, the densest in genes and displays association with a number of diseases. In addition, correlations between heliotypes associated with Psoriasis, an MHC-linked disease and methylamine epigenotypes will establish reproducible inter-individual, disease related variation of methylamine patterns. Fields of science natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-14. - Support for research infrastructures Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator GENOME RESEARCH LTD. Address The wellcome trust genome campus hinxton CB10 1SA Saffron walden United Kingdom See on map EU contribution € 0,00 Participants (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all EPIGENOMICS AG Germany EU contribution € 0,00 Address Kastanienallee 24 Berlin See on map Links Website Opens in new window
