Objective
The project aims to develop improved animal models and bioassays for TSE agents useful for infectivity and strain typing studies. They will be based on the bank vole, a wild rodent with unprecedented susceptibility to the scrapie agent. Transmission studies of animal and human TSEs will be carried out in voles, wild- type and ovine PrP Tg mice. A transfected cell line and a Tg mouse expressing the vole PrP gene will be generated for infectivity studies. Besides a high susceptibility of voles to scrapie, preliminary results showed a simultaneous resistance to BSE. Mechanisms accounting for the differential transmissibility of scrapie and BSE, will be studied by in vitro PrP conversion and in Tg mice, by means of mutated PrP vole genes. The implications of the high susceptibility of voles for scrapie epidemiology will be investigated in semi-naturalistic studies by following up the possible spread of scrapie in closed populations of voles.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
00161 ROMA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.