PROGESTERONE IN HUMAN SERUM

Project Information

Grant agreement ID: RM174

Start date

End date

Funded under

• Research and development programme (EEC) in the field of applied metrology and chemical analysis (Community Bureau of Reference - BCR), 1988-1992

Total cost No data

EU contribution € 144 000,00

Coordinated by

Academisch Ziekenhuis
Netherlands

Objective

Progesterone is a steroid hormone derived from cholesterol. In adult women, it is produced in the ovaries. An important reason for determining progesterone in serum is the assessment of female infertility.

The project includes the development of an isotope dilution - mass spectrometry (ID-MS) method for the determination of progesterone in human serum. Two serum pools will be prepared from blood collected from selected populations of donors. Each batch is to contain only endogenous progesterone.

RESULTS

The project has been completed in 1989. Six laboratories contributed to the establishment of the certified value for the progesterone concentration in each of the two serum pools. Four intercomparison exercises were necessary to set up an ID-MS procedure in each participating laboratory. The between laboratory CV was initially of about 6 %. The certified concentrations of progesterone in the serum reference materials are:
CRM 347 (10.13 +/- 0.21) nmol/l
CRM 348 (40.3 +/- 1.0) nmol/l
Details on the certification exercise are published in report EUR 12282 (1989).

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• natural sciences › chemical sciences › analytical chemistry › mass spectrometry

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Programme(s)

• FP2-BCR 4 - Research and development programme (EEC) in the field of applied metrology and chemical analysis (Community Bureau of Reference - BCR), 1988-1992

Topic(s)

Data not available

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

Academisch Ziekenhuis

• EU contribution: No data
• Address: Groningen ; Netherlands
• Total cost: No data

Participants (6)

Centro di Spettrometria di Massa

Italy

• EU contribution: No data
• Address: 501 Firenze
• Total cost: No data

Fondation de Recherche en Hormonologie

France

• EU contribution: No data
• Address: Fresnes
• Total cost: No data

National Institute for Biological Standards and Control (NIBSC)

United Kingdom

• EU contribution: No data
• Address: Blanche Lane South Mimms ; EN6 3QG Potters Bar
• Total cost: No data

Rheinische Friedrich-Wilhelms-Universität Bonn

Germany

• EU contribution: No data
• Address: Sigmund-Freud-Straße 25 ; 53127 Bonn
• Total cost: No data

Rijksuniversiteit Gent

Belgium

• EU contribution: No data
• Total cost: No data

Tenovus Institute for Cancer Research

United Kingdom

• EU contribution: No data
• Address: Cardiff
• Total cost: No data