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GLYCATED HAEMOGLOBINS

Objective



In patients who suffer from diabetes, important indicators of the overload of sugar are the fractions of haemoglobin called "glycated haemoglobins". The glycation process may affect other proteins than haemoglobin. The determination of glycated haemoglobins is therefore relevant also to prevent the long-term complications associated with diabetes by helping to control the overall carbohydrate metabolism of the patients.

The project comprises a methodological assessment aiming at the selection of techniques capable to provide reliable and reproducible results for the determination of glycated haemoglobin fractions. The project should be concluded by the preparation of a reference material.

RESULTS

Six interlaboratory trials have been carried out to improve the consistency of the results obtained by affinity chromatography and by high performance liquid chromatography (HPLC). A reference preparation has been produced from a blood haemolysate. A value was attributed to the preparation using a HPLC procedure. A fully detailed report is due within 1992.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

Bio-Rad Labs GmbH
Address

München
Germany

Participants (11)

Centre Hospitalier Universitaire Cochin
France
Address

Paris
Centre de Transfusion Sanguine
France
Address

Nancy
Hvidore Hospital
Denmark
Address

Klampenborg
Hôpital Universitaire Erasme
Belgium
Address

Bruxelles
Novo Biolabs Ltd
United Kingdom
Address

CB Cambridge
Queen's Medical Centre
United Kingdom
Address

Nottingham
Royal Sussex County Hospital
United Kingdom
Address

BN1 Brighton
UNIVERSITÀ DEGLI STUDI DI MILANO
Italy
Address

Milano
Universität Düsseldorf
Germany
Address
Auf'm Hennekamp 65
40225 Düsseldorf
Universität München
Germany
Address

München
Ziekenhuis de Weezenlanden
Netherlands
Address

Zwolle