Objective
In patients who suffer from diabetes, important indicators of the overload of sugar are the fractions of haemoglobin called "glycated haemoglobins". The glycation process may affect other proteins than haemoglobin. The determination of glycated haemoglobins is therefore relevant also to prevent the long-term complications associated with diabetes by helping to control the overall carbohydrate metabolism of the patients.
The project comprises a methodological assessment aiming at the selection of techniques capable to provide reliable and reproducible results for the determination of glycated haemoglobin fractions. The project should be concluded by the preparation of a reference material.
RESULTS
Six interlaboratory trials have been carried out to improve the consistency of the results obtained by affinity chromatography and by high performance liquid chromatography (HPLC). A reference preparation has been produced from a blood haemolysate. A value was attributed to the preparation using a HPLC procedure. A fully detailed report is due within 1992.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine endocrinology diabetes
- natural sciences biological sciences biochemistry biomolecules carbohydrates
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Coordinator
München
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.