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THYROGLOBULIN

Objective



Thyroglobulin is a protein of the thyroid gland which plays the major role in the synthesis of the thyroid hormones. The determination of serum thyroglobulin (Tg) is particularly important in the follow-up of patients who suffered from thyroid cancer. After successful therapy, the monitoring of serum Tg is carried out to assess recurrent episodes of the cancer. Elevated serum Tg levels may be an indication of metastases. Such an information gives an opportunity to treat the disease at an early stage.

The project aims at providing clinical chemists with a means of assessing (calibrating) their assay of serum thyroglobulin. The project starts with the preparation of a purified Tg extracted from human thyroid glands. Next steps might include the certification of serum reference materials.

STATUS

Following two pilot studies that concluded to the feasibility of preparing purified and stable thyroglobulin in a reproducible way, a final lot of purified Tg has been produced. The work to certify its mass concentration has started and it should be completed by the end of 1992.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

Frederiksberg Hospital
Address

Copenhagen
Denmark

Participants (14)

Academisch Medisch Centrum
Netherlands
Address

Amsterdam
Centre Hospitalier Régional
France
Address

13009 Marseille
Facultad Autonoma de Medicina
Spain
Address

Madrid
Faculté de Médicine Grange Blanche
France
Address

Lyon
Henning Berlin GmbH
Germany
Address

Berlin
Hôpital St. Pierre
Belgium
Address

Bruxelles
INSTITUT GUSTAVE ROUSSY
France
Instituto Portugues de Oncologia
Portugal
Address

Lisboa
Ruprecht-Karls-Universität Heidelberg
Germany
Address
Im Neuenheimer Feld 346
69120 Heidelberg
University of Athens
Greece
Università degli Studi di Pisa
Italy
Address

56100 Pisa
Università di calabria
Italy
Address

88100 Catanzaro
Université Catholique de Louvain
Belgium
Address

Bruxelles
Université Libre de Bruxelles
Belgium