Objective
Thyroglobulin is a protein of the thyroid gland which plays the major role in the synthesis of the thyroid hormones. The determination of serum thyroglobulin (Tg) is particularly important in the follow-up of patients who suffered from thyroid cancer. After successful therapy, the monitoring of serum Tg is carried out to assess recurrent episodes of the cancer. Elevated serum Tg levels may be an indication of metastases. Such an information gives an opportunity to treat the disease at an early stage.
The project aims at providing clinical chemists with a means of assessing (calibrating) their assay of serum thyroglobulin. The project starts with the preparation of a purified Tg extracted from human thyroid glands. Next steps might include the certification of serum reference materials.
STATUS
Following two pilot studies that concluded to the feasibility of preparing purified and stable thyroglobulin in a reproducible way, a final lot of purified Tg has been produced. The work to certify its mass concentration has started and it should be completed by the end of 1992.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
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Coordinator
Copenhagen
Denmark
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