Human chorionic gonadotropin (hCG) is a glycoprotein normally produced by the placenta. The physiological effects induced by hCG are similar to those produced by luteinizing hormone (LH), including induction of ovulation. Indirect measurement of the rapidly rising hCG concentration early in pregnancy forms the basis of most "pregnancy tests" employed today. In men or in non-pregnant women increased levels of serum hCG indicate the presence of a tumour (for example, a choriocarcinoma of the uterus). The determination of serum hCG is of particular value in monitoring the response of the tumour to chemotherapy.
The aim is similar to that of projects no 320 and 321. The approach will be the same as described for project no 320.
In 1988 an interlaboratory study was set up with 19 laboratories, to determine hCG in different serum samples. The results showed that the mean values for the major method groups are in good agreement with the all laboratory consensus means, at least in relation to lower concentrations. Future work including epitope mapping studies may start after the completion of studies on LH.
Funding SchemeCSC - Cost-sharing contracts
EH3 9YW Edinburgh
65926 Frankfurt Am Main
EN6 3QG Potters Bar