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HUMAN CHORIONIC GONADOTROPIN

Objective



Human chorionic gonadotropin (hCG) is a glycoprotein normally produced by the placenta. The physiological effects induced by hCG are similar to those produced by luteinizing hormone (LH), including induction of ovulation. Indirect measurement of the rapidly rising hCG concentration early in pregnancy forms the basis of most "pregnancy tests" employed today. In men or in non-pregnant women increased levels of serum hCG indicate the presence of a tumour (for example, a choriocarcinoma of the uterus). The determination of serum hCG is of particular value in monitoring the response of the tumour to chemotherapy.

The aim is similar to that of projects no 320 and 321. The approach will be the same as described for project no 320.

STATUS

In 1988 an interlaboratory study was set up with 19 laboratories, to determine hCG in different serum samples. The results showed that the mean values for the major method groups are in good agreement with the all laboratory consensus means, at least in relation to lower concentrations. Future work including epitope mapping studies may start after the completion of studies on LH.

Coordinator

Akademisch Ziekenhuis
Address

Brussel
Belgium

Participants (31)

BioMérieux SA
France
Address
Marcy L'etoile
69260 Charbonnières-les-bains
Bleuland Ziekenhuis
Netherlands
Address

Gouda
Boehringer Mannheim GmbH
Germany
Address

Penzberg
Cliniques Universitaires St Luc
Belgium
Address

Bruxelles
Copenhagen County Hospital
Denmark
Address

Glostrup
Dakopatts
Denmark
Address

Glostrup
Edinburgh Royal Infirmary
United Kingdom
Address

EH3 9YW Edinburgh
Eurogentec S.A.
Belgium
Address

Liège
HANNOVER MEDICAL SCHOOL
Germany
Address
Carl-neuberg-strasse 1
30625 Hannover
Hoechst AG
Germany
Address
Brüningstraße
65926 Frankfurt Am Main
Hospital de la Santa Creu i San Pau
Spain
Address

Barcelona
Hybritech Europe
Belgium
Address

Liège
INSTITUT GUSTAVE ROUSSY
France
Immunotech SA
France
Address
130 Avenue De Lattre De Tassigny
13009 Marseille
Institut des Radioéléments-Medgenix
Belgium
Address

Fleurus
Klinikum München-Großhadern
Germany
Address
Marchioninistraße 15
81377 München
Laboratoires d'Analyses Biologiques Spécialisées
France
Address

Nice
Medizinische Universität Lübeck
Germany
Address
Ratzeburger Allee 160
23562 Lübeck
National Athletic Research Centre
Greece
Address

Athens
National Institute for Biological Standards and Control (NIBSC)
United Kingdom
Address
Blanche Lane South Mimms
EN6 3QG Potters Bar
Novo Biolabs Ltd.
United Kingdom
Address

Cambridge
Nuclear Research Centre Demokritos
Greece
Address

Athens
ORIS Industrie
France
Address

Bagnols-sur-cèze
SERATEC Gesellschaft für Biotechnologie mbH
Germany
Address
Rudolf-winkel-straße 1A
37079 Göttingen
Serono Diagnostics Ltd.
United Kingdom
Address

Woking
Sorin Biomedica SpA
Italy
Address

Salluggia
St Thomas's Hospital
United Kingdom
Address

London
St. Radboud Ziekenhuis Nijmegen
Netherlands
Statens Seruminstitut
Denmark
Address

Copenhagen
UNIVERSIDADE DE COIMBRA
Portugal
Address
Paco Das Escolas
Université d'Aix-Marseille II
France
Address

13288 Marseille