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ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES (ANCA)

Objective



In the case of autoimmune diseases the organism raises antibodies against its own cells. In 1985 it was reported that anti-Neutrophil Cytoplasmic Antibodies (ANCA) -directed against components of the cytoplasm of the neutrophils- were present in the serum of patients with Wegener's granulomatosis (inflammatory vascular disease of the upper airways and lungs, also affecting the kidneys). ANCA are now commonly measured to diagnose this disease.

The project consists of a collaborative study with the aim of developing a set of assays for the detection of ANCA. The methods will be assessed in order to determine their ability to detect and quantify ANCA in a spectrum of diseases that are characterised by the inflammatory state of the blood vessels, the kidneys or the joints. This will be achieved through an interlaboratory trial to test the selected assays (in a large number of laboratories) on an elevated number of patient sera.

STATUS

The project has started in 1990 and is expected to be completed before the end of 1994. Currently performed assays were compared on a limited number of patient serum samples. At present the selection of a set of solid phase assays is performed in parallel with the characterization of the antigens.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

Academisch Ziekenhuis
Address

Leiden
Netherlands

Participants (14)

Academisch Ziekenhuis Groningen
Netherlands
Address

Groningen
Gentofte Hospital
Denmark
Address

Hellerup
Hospital Clinic i Provincial
Spain
Address

Barcelona
Hôpital Necker
France
Address
149 Rue De Sèvres
Paris
National Bacteriological Laboratory
Sweden
Address

Stockholm
Rheumaklinik Bad Bramstedt
Germany
Address

Bad Bramstedt
Royal Postgraduate Medical School
United Kingdom
Address
150,Ducane Road
W12 ONN London
Ruprecht-Karls-Universität Heidelberg
Germany
Address
Im Neuenheimer Feld 346
69120 Heidelberg
STATENS SERUM INSTITUT
Denmark
Address
Artillerivej 5
San Carlo Borromeo General Hospital
Italy
Address

20100 Milano
University of Cambridge
United Kingdom
Address
Trumpington Street
CB2 1PZ Cambridge
University of Ioannina Medical School
Greece
Address

Ioannina
Utech & Lüdeman GbR
Germany
Address

Raisdorf
Vrije Universiteit Brussel
Belgium
Address

Brussel