Objective
In the case of autoimmune diseases the organism raises antibodies against its own cells. In 1985 it was reported that anti-Neutrophil Cytoplasmic Antibodies (ANCA) -directed against components of the cytoplasm of the neutrophils- were present in the serum of patients with Wegener's granulomatosis (inflammatory vascular disease of the upper airways and lungs, also affecting the kidneys). ANCA are now commonly measured to diagnose this disease.
The project consists of a collaborative study with the aim of developing a set of assays for the detection of ANCA. The methods will be assessed in order to determine their ability to detect and quantify ANCA in a spectrum of diseases that are characterised by the inflammatory state of the blood vessels, the kidneys or the joints. This will be achieved through an interlaboratory trial to test the selected assays (in a large number of laboratories) on an elevated number of patient sera.
STATUS
The project has started in 1990 and is expected to be completed before the end of 1994. Currently performed assays were compared on a limited number of patient serum samples. At present the selection of a set of solid phase assays is performed in parallel with the characterization of the antigens.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences basic medicine immunology autoimmune diseases
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
Leiden
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.