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BLOOD GROUPING REAGENTS

Objective



The safety of blood transfusion in the European Community relies in part on the quality of the reagents used for ABO and Rh(D) typing and compatibility testing. Mistyping of donors or patients caused by defective substandard reagents can lead to clinically significant transfusion reactions, and in some cases, fatality. There are no European reference materials available for the control of the quality of the reagents in use.

The aim of this project is to prepare, with the collaboration of representatives from blood transfusion laboratories and reagent manufacturers operating within Europe, anti-A, anti-B and anti-D certified reference materials. The certification will be conducted according to agreed specifications and will include the evaluation, validation and stability study of the proposed materials. Similar work may then be envisaged for three additional standards (anti-IgG, papain and control weak anti-D and red cell panels for anti-D evaluation).

STATUS

Candidate pilot freeze-dried materials for anti-A, anti-B and anti-D are being tested and compared to existing FDA and WHO standards by the participants. The results are expected to be reported by mid 1992. Certification to be completed in 1993.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

International Blood Group Reference Laboratory
Address

BS Bristol
United Kingdom

Participants (22)

Aalborg Sygehus
Denmark
Address

Aalborg
Baxter/Dade
Switzerland
Address

Düdingen
Biotest Diagnostics
Germany
Address

Dreieich
Blood Transfusion Service Board
Ireland
Address

Dublin
Central Laboratory of the Netherlands
Netherlands
Address

Amsterdam
Croix Rouge de Belgique
Belgium
Address

Liège
Diagnostics Transfusion
France
Address

Les Ulis
East Anglia Blood Transfusion Centre
United Kingdom
Address

CB Cambridge
Finnish Red Cross Blood Transfusion
Finland
Address

Helsinki
Greek National Blood Transfusion Centre
Greece
Address

Athens
Institut Catala de la Salut
Spain
Address

Barcelona
Institut National de Transfusion Sanguine
France
Address

Paris
Institut für Transfusionmedizin
Germany
Address

Aachen
Instituto National de Sangue
Portugal
Address

Porto
National Institute for Biological Standards and Control (NIBSC)
United Kingdom
Address
Blanche Lane South Mimms
EN6 3QG Potters Bar
Organon Teknica
Belgium
Address

Turnhout
Ortho Diagnostic Systems
Belgium
Address

Antwerp
Primo Centro Transfusioni
Italy
Address

20100 Milano
Red Cross Blood Transfusion Service
Luxembourg
Scottish National Blood Transfusion Service
United Kingdom
Address

Edinburgh
University Hospital Blood Bank
Sweden
Address

Lund
Zentrallaboratorium Blutspendedienst
Switzerland
Address

Bern