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CORTICAL MECHANISM OF VISUOMOTOR TRANSFORMATION : THE ROLE OF FRONTAL AND PARIETAL AREAS

Objective


The activity of 156 individual arm related neurons was studied in the premotor cortex (area 6) while monkeys made arm movements of similar directions within different parts of 3-dimensional space. This study was aimed at describing the relationship between premotor cortical cell activity and direction of arm movement and assessing the coordinate system underlying this relationship.

The activity of 152 (97.4%) cells varied in an orderly fashion with the direction of movement, in at least some region of the work space. Premotor cortical cells fired most for a give preferred direction and less for other directions of movement. These preferred directions covered the directional continuum in a uniform fashion across the work space. As movements of similar directions were made within different parts of the work space the cells' preferred directions changed their orientation. Although these changes had different magnitudes for different cells, at the population level, they followed closely the changes in orientation of the arm necessary to move the hand from one to another part of the work space.

This shift of cells' preferred direction with the orientation of the arm in space has been observed with similar characteristics in the motor cortex.

In both premotor and motor cortices, neuronal movement population vectors provide a good description of movement direction. Unlike the individual cell preferred directions upon which they are based, movement population vectors did not change their spatial orientation across the work space, suggesting that they remain good predictors of movement direction regardless of the region of space in which movements are made.

The firing frequency of both premotor and motor cortical neurons varied significantly with the position occupied by the hand in space. These static positional effects were observed in 88.5% of premotor and 91.8% of motor cortical cells.

In a second task monkeys made movements from differing origins to a com mon end point. This task was performed within 3 different parts of space and was aimed at dissociating movement direction from movement end point. It was found that in both premotor and motor cortices virtually all cells were related to the direction and not to the end point of movement.

These data suggest that premotor and motor cortices use common mechanisms for coding arm movement direction. They also provide a basis for understanding the coordinate transformation required to move the hand toward visual targets in space.

A biologically realistic neural network is proposed that computes coordinate transformations for the command of arm reaching movements in 3-dimensional space. This model is consistent with anatomical and physiological data on the cortical areas involved in the command of these movements. Studies of the neuronal activity in the motor and premotor cortices of behaving monkeys have shown that the activity of individual arm related neurons is broadly tuned around a preferred direction of movements in 3-dimensional space. Recent data demonstrate that in both frontal areas these cell preferred directions rotate with the initial position of the arm. Furthermore, the rotation of the population of preferred directions precisely corresponds to the rotation of the arm in space.

The neural network model computes the motor command by combining the visual information concerning the orientation of the arm in space. The appropriate combination learned by the network from spontaneous movement, can be approximated by a bilinear operation that can be interpreted as a projection of the visual information on a reference frame that rotates with the arm. This bilinear combination implies that neural circuits converging on a single neuron in the motor and premotor cortices can learn and generalize the appropriate command in 2-dimensional subspace but not in the whole 3-dimensional space. However, the uniform distribution of cell preferred directions in these frontal areas can explain the computation of the correct solution by a population of cortical neurons. The model is consistent with the existing neurophysiological data and predicts how visual and somatic information can be combined in the different processing steps of the visuomotor transformation subserving visual reaching.
This project intends to describe the basic operation in the cerebral cortex of primates that transforms visual coordinates in order to control a reaching movement; it is executed by an integrated neuronal network including the parietal, the prefrontal and the motor cortical areas. This project combines three complementary approaches. The neurophysiological study relates neuronal activity with sensorimotor parameters by recording unitary cell activity in cortex of monkeys trained to perform stereotyped arm movements in a 3-D space. The neuro-anatomical description of the fine organization of corticocortical connections reveals the morphological constraints in this work. The modelisation searches a network of automata consistent with experimental results that produces a transformation of coordinates resulting in a reaching movement.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac, 101
75654 Paris
France

Participants (1)

UNIVERSITY OF ROME "LA SAPIENZA"
Italy
Address
Viale Del Policlinico Policlinico Umberto I
00161 Roma