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THE H+ ATPASE OF EUKARYOTIC CELLS PLASMA MEMBRANE: MOLECULAR STRUCTURE OF THE ENZYME AND MOLECULAR DYNAMICS OF THE COUPLING BETWEEN ATP HYDROLYSIS AND H+- TRANSPORT

Objective



The project aims at an elucidation of the molecular structure and molecular dynamics of the yeast plasma membrane H+-ATPase. This study represents a key stage to understand the general mechanism of active transport. The main objectives of this research will be the
understanding of how the phosphate transfer reaction is coupled to proton binding and transpor and how is the plasma membrane ATPase regulated. Crystals of the H+-ATPase in different states and the following X-ray structure analysis should shine additional light on the mechanism of this enzyme.

Coordinator

UNIVERSITE CATHOLIQUE DE LOUVAIN
Address
Place De L'universite 1
Louvain-la-neuve
Belgium

Participants (3)

Commissariat à l'Energie Atomique (CEA)
France
Address
Centre D'études De Saclay
91191 Gif-sur-yvette
Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV
Germany
Address
Rheinlanddamm 201
44139 Dortmund
Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV
Germany
Address
Kennedyallee 70
60596 Frankfurt Am Main