Objective
Research has been carried out into the cellular factors affecting permissiveness to parvoviruses. Direct evidence was obtained for the cytotoxic activity of nonstructural (NS) proteins. Thus, neoplastic human cells, which have incorporated a hormono-inducibile molecular clone of the nonstructural region of the prototype strain of parvovirus minutes virus of mice (MVMp), have died upon hormonal treatment. It has been shown that transcription of NS genes from the P4 promoter is enhanced in ras transformed cell lines compared to normal cells. The parvoviral oncosuppressive effect may result from the up regulation of the P4 promoter by cellular factors which are modulated as a function of oncogenic transformation. A new parvoviral deoxyribonucleic (DNA) element, nucleolin binding element (NUBE), has been identified, which forms a complex with nucleolin and which is located downstream from the P4 promoter. It is possible thatnucleolin may contribute to the regulation of the parvoviral life cycle.
Early steps in the process of malignat transformation are associated with an increase in the susceptibility of host cells to the
replication and cytopathic effect of parvoviruses. Advantage will be taken of this modulation to fish out, by means of parvoviral probes, cellular functions whose expression is modified by neoplasic transformation and which affect parvoviral DNA amplification and expression. Such cellular factors are worth identifying, both as determinants of the oncosuppressive activity of parvoviruses and as markers of the transformed state. This investigation will be conducted at two complementary levels : messenger RNAs (project 1) and proteins (project 2).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics RNA
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BRUXELLES
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.