USE OF MOLECULAR TECHNIQUES TO INVESTIGATE THE PATHOGENESIS AND PERSISTENCE OF FOOT AND MOUTH DISEASE IN LIVESTOCK AND IN A MODEL CELL CULTURE SYSTEM

Objective

Molecular biological, virological and electron microscopic techniques will be used to identify the cells in the respiratory tract of live-stock where foot-and-mouth disease virus (FMDV) initiates infection and where it persists in long-term "carrier" animals. A persistently infected BHK-21 cell system will be used as a model to investigate the nature of virus-cell interaction during long-term carriage. The anti-viral agent ribavirin, shown to eliminate FMDV from persistently infected cell cultures, will be tested for its ability to cure the carrier state in animals.

Programme(s)

• FP2-SCIENCE - Programme plan (EEC) to stimulate the international cooperation and interchange needed by European research scientists (SCIENCE), 1988-1992

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUTE FOR ANIMAL HEALTH

Address

Ash Road, Nr Woking
GU24 0NF Woking
United Kingdom

Participants (2)

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain

Address

Calle Serrano 117
Madrid

Università degli Studi di Torino

Italy

Address

Via Nizza 52
10126 Torino