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USE OF MOLECULAR TECHNIQUES TO INVESTIGATE THE PATHOGENESIS AND PERSISTENCE OF FOOT AND MOUTH DISEASE IN LIVESTOCK AND IN A MODEL CELL CULTURE SYSTEM

Objective



Molecular biological, virological and electron microscopic techniques will be used to identify the cells in the respiratory tract of live-stock where foot-and-mouth disease virus (FMDV) initiates infection and where it persists in long-term "carrier" animals. A persistently infected BHK-21 cell system will be used as a model to investigate the nature of virus-cell interaction during long-term carriage. The anti-viral agent ribavirin, shown to eliminate FMDV from persistently infected cell cultures, will be tested for its ability to cure the carrier state in animals.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUTE FOR ANIMAL HEALTH
Address
Ash Road, Nr Woking
GU24 0NF Woking
United Kingdom

Participants (2)

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Calle Serrano 117
Madrid
Università degli Studi di Torino
Italy
Address
Via Nizza 52
10126 Torino