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DYNAMICS OF THE STRUCTURAL AND MECHANO-CHEMICAL MECHANISM OF MUSCULAR CONTRACTION AND ITS CONTROL

Objective



The mechanism of muscular contraction will be investigated at the molecular level in permeabilized fibre preparations of fast-twitch skeletal rabbit muscle and insect fibrillar flight muscle.
The dynamic and structural properties of intermediates in the cross-bridge cycle will be characterised by using a variety of rapid real-time analytical methods. The results will be coordinated with those obtained from isolated actomyosin in solution and from single actin filaments that are motile and capable of sustaining force exerted by a mono-layer bed of myosin molecules.

Coordinator

Medical Research Council (MRC)
Address
20 Park Crescent
W1N 4AL London
United Kingdom

Participants (3)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue De Tolbiac, 101
75654 Paris
Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV
Germany
Address
Jahnstraße 29
69120 Heidelberg
University of Bristol
United Kingdom
Address
Senate House Tyndall Avenue
BS8 1TH Bristol