Objective
We plan to obtain biological tools (monoclonal, polyclonal antibodies and riboprobes) to examine in situ gene transcription and protein expression of a newly characterized cytokine: HILDA (Human Interleukin Da). This cytokine is produced by lymphocytes, monocytes/Macrophages and several tumor cell lines. Target cells are macrophages, embryonic stem cells, bone marrow progenitors and possibly endothelial cells. Antibodies will be prepared against HILDA and hydrophylic non-glycosylated HILDA peptides. Transcription and expression of HILDA - in comparison with other cytokines - will be studied in allotransplantation (rejection and tolerance) and in autoimmune disease (multiple sclerosis and auto-immune encephalitis) in humans and in rats.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine neurology multiple sclerosis
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences basic medicine immunology autoimmune diseases
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
44035 NANTES
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.