STUDY OF HILDA GENE TRANSCRIPTION AND HILDA PRODUCTION IN ALLOTRANSPLANTATION AND AUTO-IMMUNITY

Project Information

Grant agreement ID: SC1*0338

Project closed

Start date 1 June 1990

End date 30 May 1993

Funded under

• Programme plan (EEC) to stimulate the international cooperation and interchange needed by European research scientists (SCIENCE), 1988-1992

Total cost € 0,00

EU contribution No data

Coordinated by

UNIVERSIT DE NANTES
France

Objective

We plan to obtain biological tools (monoclonal, polyclonal antibodies and riboprobes) to examine in situ gene transcription and protein expression of a newly characterized cytokine: HILDA (Human Interleukin Da). This cytokine is produced by lymphocytes, monocytes/Macrophages and several tumor cell lines. Target cells are macrophages, embryonic stem cells, bone marrow progenitors and possibly endothelial cells. Antibodies will be prepared against HILDA and hydrophylic non-glycosylated HILDA peptides. Transcription and expression of HILDA - in comparison with other cytokines - will be studied in allotransplantation (rejection and tolerance) and in autoimmune disease (multiple sclerosis and auto-immune encephalitis) in humans and in rats.

Fields of science

• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• medical and health sciences › basic medicine › neurology › multiple sclerosis
• medical and health sciences › medical biotechnology › cells technologies › stem cells
• medical and health sciences › basic medicine › immunology › autoimmune diseases

Programme(s)

• FP2-SCIENCE - Programme plan (EEC) to stimulate the international cooperation and interchange needed by European research scientists (SCIENCE), 1988-1992

Topic(s)

Data not available

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSIT DE NANTES

• EU contribution: No data
• Address: Quai de Tourville 1 ; 44035 NANTES ; France
• Total cost: No data