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MOLECULAR BIOPHYSICS IN SINGLE LIVING CELLS APPROACHED BY OPTICAL MICROSPECTROSCOPIES : DRUG-CELL AND CELL-CELL INTERACTIONS IN CYTOTOXIC MECHANISMS

Objective



Molecular Biophysics has reached the point where it can move from model system studies to a direct intracellular approach of molecular events in single livingcells.Five Laboratories of Molecular Biophysics belonging to three European Countries propose to bring together their know how in optical microspectrometries and cellular biology in order to develop this new approach at the single cell level, to push back its limits and to demonstrate on some examples its advantages over more classical biophysical or biochemical approaches.They will concentrate their efforts on the investigation of the mechanisms of action of two families of drugs used in chemotherapy and of the mechanisms of cell-cell interaction in cytotoxicity.A part of their efforts will be devoted to the introduction of new physical parameters in the analysis(time resolution, extension of the excitation wavelength range)in order to fully exploit the possibilities offered by these spectroscopies.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

Institut Curie
Address
11 Rue Pierre Et Marie Curie
75231 Paris
France

Participants (3)

Fondazione Internazionale Biotecnologie
Italy
Address
Via Hachej 10
20129 Milano
University of Twente
Netherlands
Address
5,Drienerlolaan 5
7500 AE Enschede
Université de Reims Champagne - Ardenne
France
Address
23 Rue Boulard
51100 Reims