Objective
We propose to define and structurally interpret the molecular bases of influenza virus haemagglutinin antigenic variations; these are observed under the selective pressure of the humoral immune response. Crystallographic studies of entities involved in this process (haemagglutinin mutants, Fab fragments of antibodies specific for haemagglutinin and complexes of these with the haemagglutinin) complemented by a study of their association kinetics will allow to set this problem in a well defined frame. The affinity of a monoclonal antibody for a viral mutant selected by growth in its presence will be compared to those of the same antibody for other mutants obtained by site specific mutagenesis and located in the antigenic site this body recognizes. These results should allow us to establish whether mechanisms other than affinity lowering are involved in the selection giving rise to antigenic mutants and to analyze them.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences infectious diseases RNA viruses influenza
- medical and health sciences basic medicine immunology
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
91405 Orsay
France
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