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Generation of Drosophila enhancer-trap lines expressing a GAL4 transcriptional activator and their use in the study of Drosophila neurobiology

Objective



Enhancer-trapping in the fruitfly Drosophila is a versatile
approach for generation of cell markers and isolation of developmentally regulated genes. A recent variant of the approach,
P-GAL4 enhancer-trapping, allows in principle the expression of any cloned gene in virtually any cell type. First, we will
generate several thousand P-GAL4 enhancer-trap fly lines and make them generally available to the Drosophila research community; this resource will be of particular use to the European fly
community. Second, we will use many of the lines generated for collaborative work in developmental neurobiology. At a later date, these enchancer-trap lines may also be of use for fly
genome mapping.

Coordinator

University of Warwick
Address
Gibbet Hill Road
CV4 7AL Coventry
United Kingdom

Participants (2)

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Universidad Autonoma De Madrid, Cantoblanco
28049 Madrid
Johannes-Gutenberg-Universität Mainz
Germany
Address
Saarstraße 21
55122 Mainz